Abstract: Madecassoside (MA), a pentacyclic triterpene isolated from Centella asitica (L.), is used as a therapeutic agent in wound healing and also as an anti-inflammatory and anti-aging agent. However, the involvement of MA in skin-pigmentation has not been reported. This study was conducted to investigate the effects of MA on ultraviolet (UV)-induced melanogenesis and mechanisms in a co-culture system of keratinocytes and melanocytes. MA significantly inhibited UVR-induced melanin synthesis and melanosome transfer in the co-culture system. These effects were further demonstrated by the MA-induced inhibition of protease-activated receptor-2 expression and its signaling pathway, cyclooxygenase-2, prostaglandin E2 and prostaglandin F2 alpha in keratinocytes. The clinical efficacy of MA was confirmed on artificially tanned human skin. MA significantly reduced UV-induced melanin index at 8 weeks after topical application. Overall, the study demonstrated significant benefits of MA use in the inhibition of hyperpigmentation caused by UV irradiation.
Keywords: post-inflammatory pigmentation; madecassoside; PAR-2; UVR
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Jung, E.; Lee, J.-A.; Shin, S.; Roh, K.-B.; Kim, J.-H.; Park, D. Madecassoside Inhibits Melanin Synthesis by Blocking Ultraviolet-Induced Inflammation. Molecules 2013, 18, 15724-15736.
Jung E, Lee J-A, Shin S, Roh K-B, Kim J-H, Park D. Madecassoside Inhibits Melanin Synthesis by Blocking Ultraviolet-Induced Inflammation. Molecules. 2013; 18(12):15724-15736.
Jung, Eunsun; Lee, Jung-A; Shin, Seoungwoo; Roh, Kyung-Baeg; Kim, Jang-Hyun; Park, Deokhoon. 2013. "Madecassoside Inhibits Melanin Synthesis by Blocking Ultraviolet-Induced Inflammation." Molecules 18, no. 12: 15724-15736.