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Molecules 2013, 18(12), 15724-15736; doi:10.3390/molecules181215724
Article

Madecassoside Inhibits Melanin Synthesis by Blocking Ultraviolet-Induced Inflammation

1
, 1
, 1
, 1
, 2
 and 1,*
1 Biospectrum Life Science Institute, Eines Platz 11th FL, 442-13 Sangdaewon Dong, Seongnam City, 462-807 Gyunggi Do, Korea 2 Dermiskin Life Science Institute, 44-9 Cheongho Ri, Pyeongtaek City, 451-862 Gyunggi Do, Korea
* Author to whom correspondence should be addressed.
Received: 29 October 2013 / Revised: 10 December 2013 / Accepted: 11 December 2013 / Published: 16 December 2013
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Abstract

Madecassoside (MA), a pentacyclic triterpene isolated from Centella asitica (L.), is used as a therapeutic agent in wound healing and also as an anti-inflammatory and anti-aging agent. However, the involvement of MA in skin-pigmentation has not been reported. This study was conducted to investigate the effects of MA on ultraviolet (UV)-induced melanogenesis and mechanisms in a co-culture system of keratinocytes and melanocytes. MA significantly inhibited UVR-induced melanin synthesis and melanosome transfer in the co-culture system. These effects were further demonstrated by the MA-induced inhibition of protease-activated receptor-2 expression and its signaling pathway, cyclooxygenase-2, prostaglandin E2 and prostaglandin F2 alpha in keratinocytes. The clinical efficacy of MA was confirmed on artificially tanned human skin. MA significantly reduced UV-induced melanin index at 8 weeks after topical application. Overall, the study demonstrated significant benefits of MA use in the inhibition of hyperpigmentation caused by UV irradiation.
Keywords: post-inflammatory pigmentation; madecassoside; PAR-2; UVR post-inflammatory pigmentation; madecassoside; PAR-2; UVR
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Jung, E.; Lee, J.-A.; Shin, S.; Roh, K.-B.; Kim, J.-H.; Park, D. Madecassoside Inhibits Melanin Synthesis by Blocking Ultraviolet-Induced Inflammation. Molecules 2013, 18, 15724-15736.

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