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Molecules 2013, 18(12), 15737-15749; doi:10.3390/molecules181215737
Article

Crystal Structures and Antifungal Activities of Fluorine-Containing Thioureido Complexes with Nickel(II)

1,2, 2, 2, 3, 2,*  and 2
1 College of Pharmacy, Nantong Tichen Health School, Nantong 226007, China 2 College of Chemistry, Chemical Engineering and Materials Science, Soochow University, 199 Ren'ai Road, Suzhou 215123, China 3 School of Biology & Basic Medical Sciences, Soochow University, 199 Ren'ai Road, Suzhou 215123, China
* Author to whom correspondence should be addressed.
Received: 13 November 2013 / Revised: 3 December 2013 / Accepted: 5 December 2013 / Published: 17 December 2013
(This article belongs to the Special Issue Fluorine Chemistry)
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Abstract

Ni(II) complexes with N-2-fluorobenzoylpiperidine-1-carbothioimidate (L2), N-4-fluorobenzoylpiperidine-1-carbothioimidate (L3), N-2-fluorobenzoylmorpholine- 1-carbothioimidate (L5) and N-4-fluorobenzoylmorpholine-1-carbothioimidate (L6)  have been synthesized and characterized by elemental analysis, FTIR and 1H-NMR. The crystal structures of three ligands (HL2, HL3 and HL6) and the corresponding Ni(II) complexes ([Ni(L2)2], [Ni(L3)2] and [Ni(L6)2]) have been determined by X-ray diffraction. The antifungal activities of the Ni(II) complexes together and the corresponding ligands against the fungi Botrytis cinerea, Trichoderma spp., Myrothecium and Verticillium spp. have been investigated. The experimental results showed that the ligands and their complexes have antifungal abilities. When the fluorine was substituted on the para-benzoyl moiety, the antifungal activity of the ligands was obviously increased. Moreover, the ligands were stronger than their complexes in inhibiting fungal activities. The antifungal ability of HL6 is especially strong, and similar to that of the commercial fungicide fluconazole.
Keywords: fluorobenzoyl thioureas; Ni(II) complexes; crystal structures; antifungal activity fluorobenzoyl thioureas; Ni(II) complexes; crystal structures; antifungal activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Li, C.; Yang, W.; Liu, H.; Li, M.; Zhou, W.; Xie, J. Crystal Structures and Antifungal Activities of Fluorine-Containing Thioureido Complexes with Nickel(II). Molecules 2013, 18, 15737-15749.

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