Open AccessThis article is
- freely available
In Vitro and In Vivo Antiangiogenic Activity of Caged Polyprenylated Xanthones Isolated from Garcinia hanburyi Hook. f.
State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, Sichuan, China
These authors contributed equally to the work.
* Author to whom correspondence should be addressed.
Received: 16 September 2013; in revised form: 3 December 2013 / Accepted: 4 December 2013 / Published: 11 December 2013
Abstract: Eleven known caged polyprenylated xanthones 1–11 were isolated from the resin of Garcinia hanburyi Hook. f., and their structures were identified by their MS, NMR and UV spectra. These xanthones showed significant cytotoxicities against four human cancer cell lines (HeLa, A549, HCT-116, and HepG-2) and strong inhibition against the proliferation of the HUVEC cell line in vitro by the MTT method. Furthermore, in an in vivo zebrafish model, xanthones 3 (morellic acid), 7 (gambogenin) and 9 (isogambogenic acid) showed comparable antiangiogenic activities with less toxicities than xanthone 1 (gambogic acid), as evaluated by death and heart rates of treated zebrafish. Xanthone 7 exhibited antiangiogenic activity with no toxicity at concentrations ranging from 8 µM to 16 µM. Meanwhile, xanthones 1, 3, 7 and 9 strongly inhibited the migration of HUVEC at a low concentration of 0.5 µM in HUVEC cell migration assay in vitro. Taken together, these findings strongly suggest that xanthone 7 might be a novel angiogenesis inhibitor.
Keywords: Garcinia hanburyi; caged polyprenylated xanthone; gambogic acid; cytotoxicity; angiogenesis; zebrafish
Article StatisticsClick here to load and display the download statistics.
Notes: Multiple requests from the same IP address are counted as one view.
Cite This Article
MDPI and ACS Style
Yang, J.; He, S.; Li, S.; Zhang, R.; Peng, A.; Chen, L. In Vitro and In Vivo Antiangiogenic Activity of Caged Polyprenylated Xanthones Isolated from Garcinia hanburyi Hook. f.. Molecules 2013, 18, 15305-15313.
Yang J, He S, Li S, Zhang R, Peng A, Chen L. In Vitro and In Vivo Antiangiogenic Activity of Caged Polyprenylated Xanthones Isolated from Garcinia hanburyi Hook. f.. Molecules. 2013; 18(12):15305-15313.
Yang, Jianhong; He, Shichao; Li, Shucai; Zhang, Ronghong; Peng, Aihua; Chen, Lijuan. 2013. "In Vitro and In Vivo Antiangiogenic Activity of Caged Polyprenylated Xanthones Isolated from Garcinia hanburyi Hook. f.." Molecules 18, no. 12: 15305-15313.