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Molecules 2013, 18(12), 14892-14919; doi:10.3390/molecules181214892
Review

C-4 Gem-Dimethylated Oleanes of Gymnema sylvestre and Their Pharmacological Activities

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Received: 27 September 2013; in revised form: 21 November 2013 / Accepted: 22 November 2013 / Published: 4 December 2013
(This article belongs to the Section Metabolites)
Download PDF [344 KB, updated 18 June 2014; original version uploaded 18 June 2014]
Abstract: Gymnema sylvestre R. Br., one of the most important medicinal plants of the Asclepiadaceae family, is a herb distributed throughout the World, predominantly in tropical countries. The plant, widely used for the treatment of diabetes and as a diuretic in Indian proprietary medicines, possesses beneficial digestive, anti-inflammatory, hypoglycemic and anti-helmentic effects. Furthermore, it is believed to be useful in the treatment of dyspepsia, constipation, jaundice, hemorrhoids, cardiopathy, asthma, bronchitis and leucoderma. A literature survey revealed that some other notable pharmacological activities of the plant such as anti-obesity, hypolipidemic, antimicrobial, free radical scavenging and anti-inflammatory properties have been proven too. This paper aims to summarize the chemical and pharmacological reports on a large group of C-4 gem-dimethylated pentacyclic triterpenoids from Gymnema sylvestre.
Keywords: Gymnema sylvestre; triterpenoids; oleanes; pharmacological activities; phytochemistry Gymnema sylvestre; triterpenoids; oleanes; pharmacological activities; phytochemistry
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Di Fabio, G.; Romanucci, V.; Zarrelli, M.; Giordano, M.; Zarrelli, A. C-4 Gem-Dimethylated Oleanes of Gymnema sylvestre and Their Pharmacological Activities. Molecules 2013, 18, 14892-14919.

AMA Style

Di Fabio G, Romanucci V, Zarrelli M, Giordano M, Zarrelli A. C-4 Gem-Dimethylated Oleanes of Gymnema sylvestre and Their Pharmacological Activities. Molecules. 2013; 18(12):14892-14919.

Chicago/Turabian Style

Di Fabio, Giovanni; Romanucci, Valeria; Zarrelli, Mauro; Giordano, Michele; Zarrelli, Armando. 2013. "C-4 Gem-Dimethylated Oleanes of Gymnema sylvestre and Their Pharmacological Activities." Molecules 18, no. 12: 14892-14919.


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