Molecules 2013, 18(12), 14892-14919; doi:10.3390/molecules181214892
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C-4 Gem-Dimethylated Oleanes of Gymnema sylvestre and Their Pharmacological Activities

1 Department of Chemical Sciences, University Federico II, Complesso Universitario Monte S. Angelo, Via Cintia 4, Napoli 80126, Italy 2 IMCB-Institute of Composite and Biomedical Materials CNR–National Research Council P E Fermi, (Granatello) Portici, Napoli 80055, Italy
* Author to whom correspondence should be addressed.
Received: 27 September 2013; in revised form: 21 November 2013 / Accepted: 22 November 2013 / Published: 4 December 2013
(This article belongs to the Section Natural Products)
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Abstract: Gymnema sylvestre R. Br., one of the most important medicinal plants of the Asclepiadaceae family, is a herb distributed throughout the World, predominantly in tropical countries. The plant, widely used for the treatment of diabetes and as a diuretic in Indian proprietary medicines, possesses beneficial digestive, anti-inflammatory, hypoglycemic and anti-helmentic effects. Furthermore, it is believed to be useful in the treatment of dyspepsia, constipation, jaundice, hemorrhoids, cardiopathy, asthma, bronchitis and leucoderma. A literature survey revealed that some other notable pharmacological activities of the plant such as anti-obesity, hypolipidemic, antimicrobial, free radical scavenging and anti-inflammatory properties have been proven too. This paper aims to summarize the chemical and pharmacological reports on a large group of C-4 gem-dimethylated pentacyclic triterpenoids from Gymnema sylvestre.
Keywords: Gymnema sylvestre; triterpenoids; oleanes; pharmacological activities; phytochemistry

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MDPI and ACS Style

Di Fabio, G.; Romanucci, V.; Zarrelli, M.; Giordano, M.; Zarrelli, A. C-4 Gem-Dimethylated Oleanes of Gymnema sylvestre and Their Pharmacological Activities. Molecules 2013, 18, 14892-14919.

AMA Style

Di Fabio G, Romanucci V, Zarrelli M, Giordano M, Zarrelli A. C-4 Gem-Dimethylated Oleanes of Gymnema sylvestre and Their Pharmacological Activities. Molecules. 2013; 18(12):14892-14919.

Chicago/Turabian Style

Di Fabio, Giovanni; Romanucci, Valeria; Zarrelli, Mauro; Giordano, Michele; Zarrelli, Armando. 2013. "C-4 Gem-Dimethylated Oleanes of Gymnema sylvestre and Their Pharmacological Activities." Molecules 18, no. 12: 14892-14919.

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