Next Article in Journal
C-4 Gem-Dimethylated Oleanes of Gymnema sylvestre and Their Pharmacological Activities
Previous Article in Journal
Immunomodulatory Effects of Hedysarum polybotrys Extract in Mice Macrophages, Splenocytes and Leucopenia
Molecules 2013, 18(12), 14876-14891; doi:10.3390/molecules181214876
Article

Design, Synthesis, Biological Activities and 3D-QSAR of New N,N'-Diacylhydrazines Containing 2,4-Dichlorophenoxy Moieties

1,2
, 3
, 3
, 3,* , 4
 and 2
Received: 21 October 2013; in revised form: 27 November 2013 / Accepted: 28 November 2013 / Published: 3 December 2013
Download PDF [430 KB, updated 18 June 2014; original version uploaded 18 June 2014]
Abstract: A series of new N,N'-diacylhydrazine derivatives were designed and synthesized. Their structures were verified by 1H-NMR, MS and elemental analysis. The herbicidal activities and plant growth regulating activity of these N,N'-diacylhydrazines were evaluated. The herbicidal activity results showed that most of these N,N'-diacyl-hydrazines showed excellent in vivo activities against Echinochloa crus-galli, Digitaria sanguinalis, Brassica napus, Amaranthus retroflerus. Most of them exhibited higher herbicidal activities against dicotyledonous weeds than monocotyledonous weeds. To further investigate the structure-activity relationship, comparative molecular field analysis (CoMFA) was performed on the basis of herbicidal activity data. Both the steric and electronic field distributions of CoMFA are in good agreement in this work.
Keywords: N,N'-diacylhydrazines; herbicidal activity; plant growth regulate activity; synthesis; 3D-QSAR N,N'-diacylhydrazines; herbicidal activity; plant growth regulate activity; synthesis; 3D-QSAR
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Sun, G.-X.; Sun, Z.-H.; Yang, M.-Y.; Liu, X.-H.; Ma, Y.; Wei, Y.-Y. Design, Synthesis, Biological Activities and 3D-QSAR of New N,N'-Diacylhydrazines Containing 2,4-Dichlorophenoxy Moieties. Molecules 2013, 18, 14876-14891.

AMA Style

Sun G-X, Sun Z-H, Yang M-Y, Liu X-H, Ma Y, Wei Y-Y. Design, Synthesis, Biological Activities and 3D-QSAR of New N,N'-Diacylhydrazines Containing 2,4-Dichlorophenoxy Moieties. Molecules. 2013; 18(12):14876-14891.

Chicago/Turabian Style

Sun, Guo-Xiang; Sun, Zhao-Hui; Yang, Ming-Yan; Liu, Xing-Hai; Ma, Yi; Wei, Yun-Yang. 2013. "Design, Synthesis, Biological Activities and 3D-QSAR of New N,N'-Diacylhydrazines Containing 2,4-Dichlorophenoxy Moieties." Molecules 18, no. 12: 14876-14891.


Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert