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Molecules 2013, 18(11), 13904-13909; doi:10.3390/molecules181113904
Communication

A Bicyclic Diterpenoid with a New 15,16-Dinorlabdane Carbon Skeleton from Leonurus japonicus and Its Coagulant Bioactivity

1,2
,
1,3,*  and 3
1 State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Sichuan Province and Ministry of Science and Technology, Chengdu 610075, China 2 School of Life Sciences, Sichuan University, Chengdu 610064, China 3 Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China
* Author to whom correspondence should be addressed.
Received: 10 October 2013 / Revised: 29 October 2013 / Accepted: 5 November 2013 / Published: 11 November 2013
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Abstract

A new 15,16-dinorlabdane diterpenoid 1 and a known labdane diterpenoid 2, together with three known ergosterols 35, were isolated from the EtOAc-soluble portion of the EtOH extract of Leonurus japonicus. Their structures were elucidated by physical and spectroscopic analysis. Compound 1 showed in vitro coagulant activity in the APTT, PT, TT, and FIB assays.
Keywords: Leonurus japonicus; dinorlabdane diterpenoid; coagulant activity Leonurus japonicus; dinorlabdane diterpenoid; coagulant activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Peng, F.; Xiong, L.; Zhao, X.-M. A Bicyclic Diterpenoid with a New 15,16-Dinorlabdane Carbon Skeleton from Leonurus japonicus and Its Coagulant Bioactivity. Molecules 2013, 18, 13904-13909.

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