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Molecules 2013, 18(11), 13904-13909; doi:10.3390/molecules181113904
Communication

A Bicyclic Diterpenoid with a New 15,16-Dinorlabdane Carbon Skeleton from Leonurus japonicus and Its Coagulant Bioactivity

1,2
,
1,3,*  and 3
1 State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Sichuan Province and Ministry of Science and Technology, Chengdu 610075, China 2 School of Life Sciences, Sichuan University, Chengdu 610064, China 3 Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China
* Author to whom correspondence should be addressed.
Received: 10 October 2013 / Revised: 29 October 2013 / Accepted: 5 November 2013 / Published: 11 November 2013
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Abstract

A new 15,16-dinorlabdane diterpenoid 1 and a known labdane diterpenoid 2, together with three known ergosterols 35, were isolated from the EtOAc-soluble portion of the EtOH extract of Leonurus japonicus. Their structures were elucidated by physical and spectroscopic analysis. Compound 1 showed in vitro coagulant activity in the APTT, PT, TT, and FIB assays.
Keywords: Leonurus japonicus; dinorlabdane diterpenoid; coagulant activity Leonurus japonicus; dinorlabdane diterpenoid; coagulant activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Peng, F.; Xiong, L.; Zhao, X.-M. A Bicyclic Diterpenoid with a New 15,16-Dinorlabdane Carbon Skeleton from Leonurus japonicus and Its Coagulant Bioactivity. Molecules 2013, 18, 13904-13909.

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