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Molecules 2013, 18(11), 13218-13227; doi:10.3390/molecules181113218
Article

One Lignanoid Compound and Four Triterpenoid Compounds with Anti-Inflammatory Activity from the Leaves of Elaeagnus oldhamii Maxim.

1,†, 2,†, 1, 1, 3, 1,*  and 1,4,*
Received: 4 September 2013 / Revised: 10 October 2013 / Accepted: 22 October 2013 / Published: 25 October 2013
(This article belongs to the Section Metabolites)
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Abstract

One lignanoid compound, isoamericanol B (1), along with four triterpenoid compounds—cis-3-O-p-hydroxycinnamoyloleanolic acid (2), trans-3-O-p-hydroxy cinnamoyloleanolic acid (3), cis-3-O-p-hydroxycinnamoylursolic acid (4), trans-3-O-p-hydroxycinnamoylursolic acid (5) have been isolated for the first time from the leaves of Elaeagnus oldhamii Maxim. Compounds 14 significantly inhibited the expression of NO (nitric oxide) produced in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. The IC50 value for inhibition of nitrite production of compound 1 was about 10.3 ± 0.4 μg/mL. In the cell viability test, however, among compounds 14 compound 1 did not significantly change cell viability. Therefore, in this study compound 1 possessed anti-inflammatory effects. The result suggests compound 1 as a potential lead compound for the treatment of inflammatory diseases.
Keywords: traditional herbal medicine; Elaeagnus oldhamii Maxim.; lignanoid; triterpenoid; anti-inflammation traditional herbal medicine; Elaeagnus oldhamii Maxim.; lignanoid; triterpenoid; anti-inflammation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Liao, C.-R.; Ho, Y.-L.; Huang, G.-J.; Yang, C.S.; Chao, C.-Y.; Chang, Y.-S.; Kuo, Y.-H. One Lignanoid Compound and Four Triterpenoid Compounds with Anti-Inflammatory Activity from the Leaves of Elaeagnus oldhamii Maxim.. Molecules 2013, 18, 13218-13227.

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