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Molecules 2013, 18(10), 12937-12950; doi:10.3390/molecules181012937
Article

Antioxidant Activity and Anti-Adipogenic Effects of Wild Herbs Mainly Cultivated in Korea

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Received: 13 September 2013; Accepted: 9 October 2013 / Published: 17 October 2013
(This article belongs to the Section Metabolites)
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Abstract: Wild herbs, which are edible plants that grow in mountainous areas, have diverse biological effects such as anti-obesity and anti-cancer activities. The aim of this study was to evaluate the total phenolic and flavonoid contents as well as the antioxidant activity of methanol extracts of Aster scaber, Ligularia fischeri, Kalopanax pictus, Codonopsis lanceolata, and Cirsium setidens and to assess their effects on lipid accumulation and reactive oxygen species (ROS) production during adipogenesis of 3T3-L1 cells. The results revealed that among the five studied wild herb extracts, Ligularia fischeri showed the highest total phenolic contents (215.8 ± 14.2 mg GAE/g) and Aster scaber showed the highest total flavonoid content (103.9 ± 3.4 mg RE/g). Furthermore, Aster scaber and Ligularia fischeri extracts showed higher antioxidant activity than the other wild herbs. Regarding anti-adipogenic activity, the Cirsium setidens extract significantly inhibited lipid accumulation (~80%) and ROS production (~50%) during adipogenesis of 3T3-L1 cells compared with control cells. These results suggest that wild herbs could be used for the development of functional foods as well as health promoting and pharmaceutical agents.
Keywords: wild herb; antioxidant assay; 3T3-L1; total phenolic content; correlation coefficients wild herb; antioxidant assay; 3T3-L1; total phenolic content; correlation coefficients
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Lee, Y.-J.; Kim, D.-B.; Lee, J.S.; Cho, J.-H.; Kim, B.K.; Choi, H.-S.; Lee, B.-Y.; Lee, O.-H. Antioxidant Activity and Anti-Adipogenic Effects of Wild Herbs Mainly Cultivated in Korea. Molecules 2013, 18, 12937-12950.

AMA Style

Lee Y-J, Kim D-B, Lee JS, Cho J-H, Kim BK, Choi H-S, Lee B-Y, Lee O-H. Antioxidant Activity and Anti-Adipogenic Effects of Wild Herbs Mainly Cultivated in Korea. Molecules. 2013; 18(10):12937-12950.

Chicago/Turabian Style

Lee, Young-Jun; Kim, Dan-Bi; Lee, Jong S.; Cho, Ju-Hyun; Kim, Bong K.; Choi, Hyeon-Son; Lee, Boo-Yong; Lee, Ok-Hwan. 2013. "Antioxidant Activity and Anti-Adipogenic Effects of Wild Herbs Mainly Cultivated in Korea." Molecules 18, no. 10: 12937-12950.


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