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Molecules 2013, 18(10), 12707-12724; doi:10.3390/molecules181012707
Article

Heteroaryl Chalcones: Design, Synthesis, X-ray Crystal Structures and Biological Evaluation

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Received: 11 September 2013; in revised form: 1 October 2013 / Accepted: 9 October 2013 / Published: 15 October 2013
(This article belongs to the Section Organic Synthesis)
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Abstract: Chalcone derivatives have attracted increasing attention due to their numerous pharmacological activities. Changes in their structures have displayed high degree of diversity that has proven to result in a broad spectrum of biological activities. The present study highlights the synthesis of some halogen substituted chalcones 3(ai) containing the 5-chlorothiophene moiety, their X-ray crystal structures and the evaluation of possible biological activities such as antibacterial, antifungal and reducing power abilities. The results indicate the tested compounds show a varied range of inhibition values against all the tested microbial strains. Compound 3c with a p-fluoro substituent on the phenyl ring exhibits elevated antimicrobial activity, whereas the compounds 3e and 3f displayed the least antimicrobial activities. The compounds 3d, 3e, 3f and 3i showed good ferric and cupric reducing abilities, and the compounds 3b and 3c showed the weakest reducing power in the series.
Keywords: heteroaryl; antimicrobial; reducing; substituent; overlay heteroaryl; antimicrobial; reducing; substituent; overlay
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Kumar, C.S.C.; Loh, W.-S.; Ooi, C.W.; Quah, C.K.; Fun, H.-K. Heteroaryl Chalcones: Design, Synthesis, X-ray Crystal Structures and Biological Evaluation. Molecules 2013, 18, 12707-12724.

AMA Style

Kumar CSC, Loh W-S, Ooi CW, Quah CK, Fun H-K. Heteroaryl Chalcones: Design, Synthesis, X-ray Crystal Structures and Biological Evaluation. Molecules. 2013; 18(10):12707-12724.

Chicago/Turabian Style

Kumar, C. S.C.; Loh, Wan-Sin; Ooi, Chin W.; Quah, Ching K.; Fun, Hoong-Kun. 2013. "Heteroaryl Chalcones: Design, Synthesis, X-ray Crystal Structures and Biological Evaluation." Molecules 18, no. 10: 12707-12724.



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