Chemical Constituents from the Roots of Ranunculus ternatus and their Inhibitory Effects on Mycobacterium tuberculosis
Abstract
:1. Introduction
2. Results and Discussion
No. | 1 | 2 | ||
---|---|---|---|---|
δH | δC | δH | δC | |
1 | 174.4 | 174.2 | ||
2 | 4.30 (dd, 1H, 8.0, 5.2) | 71.9 | 4.25 (dd, 1H, 8.0, 5.6) | 71.9 |
3 | 3.04 (dd, 1H, 13.6, 5.2) | 36.8 | 3.00 (dd, 1H, 13.6, 5.6) | 37.0 |
2.91 (dd, 1H, 13.6, 8.0) | 2.93 (dd, 1H, 13.6, 8.0) | |||
4 | 3.64 (s, 3H) | 50.9 | 4.02 (t, 2H, 6.8) | 64.3 |
5 | 1.52 (m, 2H) | 30.3 | ||
6 | 1.29 (m, 2H) | 18.6 | ||
7 | 0.90 (t, 3H, 7.2) | 12.6 | ||
CO | 197.7 | 197.7 | ||
1' | 128.9 | 128.7 | ||
2' | 130.3 | 130.4 | ||
3' | 6.79 (s, 1H) | 117.1 | 6.80 (s, 1H) | 117.0 |
4' | 142.6 | 142.7 | ||
5' | 147.5 | 147.4 | ||
6' | 6.79 (s, 1H) | 117.9 | 6.80 (s, 1H) | 118.0 |
1'' | 130.1 | 130.1 | ||
2'' | 7.28 (d, 1H, 2.0) | 116.8 | 7.29 (d, 1H, 2.0) | 116.8 |
3'' | 144.8 | 144.9 | ||
4'' | 150.9 | 150.9 | ||
5'' | 6.82 (d, 1H, 8.0) | 114.2 | 6.81 (d, 1H, 8.0) | 114.2 |
6'' | 7.17 (dd, 1H, 8.0, 2.0) | 124.4 | 7.17 (dd, 1H, 8.0, 2.0) | 124.4 |
Sample | Control | |||||
---|---|---|---|---|---|---|
1 | 2 | 3 | 4 | Mixture of 1 + 3 (1:1) | Mixture of 1 + 4 (1:1) | |
41.67 ± 14.43 * | 266.67 ± 115.47 | 83.33 ± 28.87 * | 66.67 ± 28.87 | 83.33 ± 28.87 * | 20.83 ± 7.22 * | 2.08 ± 0.90 |
3. Experimental
3.1. General Procedures
3.2. Plant Material
3.3. Extraction and Isolation
3.3.1. Methyl (R)-3-[2-(3,4-dihydroxybenzoyl)-4,5-dihydroxyphenyl]-2-hydroxypropanoate (1)
3.3.2. n-Butyl (R)-3-[2-(3,4-dihydroxybenzoyl)-4,5-dihydroxyphenyl]-2-hydroxypropanoate "(2)
3.4. Anti-Tuberculosis Activity
4. Conclusions
Supplementary Materials
Acknowledgments
Conflicts of Interest
References
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Deng, K.-Z.; Xiong, Y.; Zhou, B.; Guan, Y.-M.; Luo, Y.-M. Chemical Constituents from the Roots of Ranunculus ternatus and their Inhibitory Effects on Mycobacterium tuberculosis. Molecules 2013, 18, 11859-11865. https://doi.org/10.3390/molecules181011859
Deng K-Z, Xiong Y, Zhou B, Guan Y-M, Luo Y-M. Chemical Constituents from the Roots of Ranunculus ternatus and their Inhibitory Effects on Mycobacterium tuberculosis. Molecules. 2013; 18(10):11859-11865. https://doi.org/10.3390/molecules181011859
Chicago/Turabian StyleDeng, Ke-Zhong, Ying Xiong, Bin Zhou, Yong-Mei Guan, and Yong-Ming Luo. 2013. "Chemical Constituents from the Roots of Ranunculus ternatus and their Inhibitory Effects on Mycobacterium tuberculosis" Molecules 18, no. 10: 11859-11865. https://doi.org/10.3390/molecules181011859