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Molecules 2013, 18(10), 11859-11865; doi:10.3390/molecules181011859

Chemical Constituents from the Roots of Ranunculus ternatus and their Inhibitory Effects on Mycobacterium tuberculosis

2,* , 3
1 Beijing University of Chinese Medicine, Beijing 100029, China 2 Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China 3 Jiangxi Science and Technology Normal University, Nanchang 330038, China
* Authors to whom correspondence should be addressed.
Received: 12 August 2013 / Revised: 14 September 2013 / Accepted: 17 September 2013 / Published: 25 September 2013
(This article belongs to the Section Natural Products)
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Two new benzophenones, methyl (R)-3-[2-(3,4-dihydroxybenzoyl)-4,5-dihydroxyphenyl]-2-hydroxypropanoate (1) and n-butyl (R)-3-[2-(3,4-dihydroxybenzoyl)-4,5-dihydroxyphenyl]-2-hydroxypropanoate (2), were isolated from the roots of Ranunculus ternatus along with the two known compounds vanillic acid (3) and gallic acid (4). Their structures were elucidated by physical and spectroscopic analysis. In addition, compound 1 exhibited obvious activity against tuberculosis, while the activity of a 1:1 mixture of compound 1 plus 4 is better than that of 1 alone.
Keywords: Ranunculus ternatus; benzophenones; tuberculosis Ranunculus ternatus; benzophenones; tuberculosis
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Deng, K.-Z.; Xiong, Y.; Zhou, B.; Guan, Y.-M.; Luo, Y.-M. Chemical Constituents from the Roots of Ranunculus ternatus and their Inhibitory Effects on Mycobacterium tuberculosis. Molecules 2013, 18, 11859-11865.

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