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Molecules 2013, 18(10), 11836-11841; doi:10.3390/molecules181011836

The Effect of Butanolides from Cinnamomum tenuifolium on Platelet Aggregation

1
Department of Physical Therapy, School of Medical and Health Sciences, Fooyin University, Ta-Liao District, Kaohsiung 83102, Taiwan
2
Department of Health Beauty, School of Medical and Health Sciences, Fooyin University, Ta-Liao District, Kaohsiung 83102, Taiwan
3
Department of Medical Laboratory Science and Biotechnology, School of Medical and Health Sciences, Fooyin University, Ta-Liao District, Kaohsiung 83102, Taiwan
*
Authors to whom correspondence should be addressed.
Received: 10 July 2013 / Revised: 27 August 2013 / Accepted: 6 September 2013 / Published: 25 September 2013
(This article belongs to the Section Natural Products)
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Abstract

This study investigated the effects of isotenuifolide and tenuifolide B from the stems of Cinnamomum tenuifolium on adenosine diphosphate (ADP)-induced human platelet aggregation. Treatment of human platelet-rich plasma with isotenuifolide (1 and 2 μg/μL) and tenuifolide B (1, 2 and 4 μg/μL) did not have any significant effect on human platelet aggregation in vitro, however, treatment of human platelet-rich plasma with isotenuifolide (4 μg/μL) resulted in an inhibitory effect on platelet aggregation, suggesting the potential of this compound as an anti-atherosclerogenic agent in humans. Isotenuifolide is a new butanolide compound, whose structure was characterized by spectral analyses.
Keywords: Cinnamomum tenuifolium; isotenuifolide; tenuifolide B; platelet aggregation Cinnamomum tenuifolium; isotenuifolide; tenuifolide B; platelet aggregation
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Dong, H.-P.; Wu, H.-M.; Chen, S.-J.; Chen, C.-Y. The Effect of Butanolides from Cinnamomum tenuifolium on Platelet Aggregation. Molecules 2013, 18, 11836-11841.

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