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Molecules 2013, 18(10), 11836-11841; doi:10.3390/molecules181011836
Article

The Effect of Butanolides from Cinnamomum tenuifolium on Platelet Aggregation

1,* , 2
, 2
 and 3,*
1 Department of Physical Therapy, School of Medical and Health Sciences, Fooyin University, Ta-Liao District, Kaohsiung 83102, Taiwan 2 Department of Health Beauty, School of Medical and Health Sciences, Fooyin University, Ta-Liao District, Kaohsiung 83102, Taiwan 3 Department of Medical Laboratory Science and Biotechnology, School of Medical and Health Sciences, Fooyin University, Ta-Liao District, Kaohsiung 83102, Taiwan
* Authors to whom correspondence should be addressed.
Received: 10 July 2013 / Revised: 27 August 2013 / Accepted: 6 September 2013 / Published: 25 September 2013
(This article belongs to the Section Metabolites)
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Abstract

This study investigated the effects of isotenuifolide and tenuifolide B from the stems of Cinnamomum tenuifolium on adenosine diphosphate (ADP)-induced human platelet aggregation. Treatment of human platelet-rich plasma with isotenuifolide (1 and 2 μg/μL) and tenuifolide B (1, 2 and 4 μg/μL) did not have any significant effect on human platelet aggregation in vitro, however, treatment of human platelet-rich plasma with isotenuifolide (4 μg/μL) resulted in an inhibitory effect on platelet aggregation, suggesting the potential of this compound as an anti-atherosclerogenic agent in humans. Isotenuifolide is a new butanolide compound, whose structure was characterized by spectral analyses.
Keywords: Cinnamomum tenuifolium; isotenuifolide; tenuifolide B; platelet aggregation Cinnamomum tenuifolium; isotenuifolide; tenuifolide B; platelet aggregation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Dong, H.-P.; Wu, H.-M.; Chen, S.-J.; Chen, C.-Y. The Effect of Butanolides from Cinnamomum tenuifolium on Platelet Aggregation. Molecules 2013, 18, 11836-11841.

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