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Molecules 2013, 18(10), 11824-11835; doi:10.3390/molecules181011824
Article

Improved Quality Control Method for Prescriptions of Polygonum capitatum through Simultaneous Determination of Nine Major Constituents by HPLC Coupled with Triple Quadruple Mass Spectrometry

1,2,†, 1,3,†, 1, 1 and 1,*
1 Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China 2 Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China 3 Hunan University of Chinese Medicine, Changsha 410208, China These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 13 June 2013 / Revised: 28 August 2013 / Accepted: 4 September 2013 / Published: 25 September 2013
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Abstract

As a traditional Miao-nationality medicinal plant, Polygonum capitatum has been used in clinical practice for several thousand years. Its prescriptions, including three dosage forms: granules, capsule and tablet are known by the brand name Relinqing® and have played an indispensable role in the treatment of urinary system infection, pyelonephritis and kidney stones. However, no study about the comprehensive quality evaluation of Relinqing® has been reported. In the present paper, a method for the simultaneous determination of nine major compounds in three dosage forms of Relinqing® using HPLC coupled with triple quadrupole mass spectrometry (HPLC-QQQ MS) was established to comprehensively evaluate their quality. The nine compounds, including four phenolic acids, four flavonoids and a lignin, were analyzed with acceptable linear regression relationship (r2, 0.9923–0.9992), precision (RSD, 1.25%–2.78%), repeatability (RSD, 2.05%%–3.47%), stability (RSD, 1.84%–3.72%) and recovery (93.60%–108.54%, RSD ≤ 3.67%). The present study fills the gap in the multivariate quality control of Relinqing® and provides a valuable reference for quality standards and dosage reforming of this traditional Chinese medicine.
Keywords: Polygonum capitatum; Relinqing®; HPLC-QQQ MS; quality control Polygonum capitatum; Relinqing®; HPLC-QQQ MS; quality control
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Zhang, K.-X.; Wang, Y.-S.; Jing, W.-G.; Zhang, J.; Liu, A. Improved Quality Control Method for Prescriptions of Polygonum capitatum through Simultaneous Determination of Nine Major Constituents by HPLC Coupled with Triple Quadruple Mass Spectrometry. Molecules 2013, 18, 11824-11835.

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