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Molecules 2013, 18(1), 244-262; doi:10.3390/molecules18010244
Article

Characterization of Flavonoids and Naphthopyranones in Methanol Extracts of Paepalanthus chiquitensis Herzog by HPLC-ESI-IT-MSn and Their Mutagenic Activity

1,2, 2, 2, 1, 3, 1,4 and 1,*
1 Department of Organic Chemistry, Institute of Chemistry, UNESP — Sao Paulo State University, Araraquara CEP 14800-900, Sao Paulo, Brazil 2 Department of Biological Sciences, Faculty of Pharmaceutical Sciences of Araraquara, UNESP — Sao Paulo State University, Araraquara CEP 14801-902, Sao Paulo, Brazil 3 Institute of Biosciences, Sao Paulo University, Sao Paulo CEP 05508-900, Sao Paulo, Brazil 4 Experimental Campus of Sao Vicente, UNESP — Sao Paulo State University, Sao Vicente CEP 11350-000, Sao Paulo, Brazil
* Author to whom correspondence should be addressed.
Received: 28 November 2012 / Revised: 11 December 2012 / Accepted: 18 December 2012 / Published: 27 December 2012
(This article belongs to the Section Metabolites)
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Abstract

A HPLC-ESI-IT-MSn method, based on high-performance liquid chromatography coupled to electrospray negative ionization multistage ion trap mass spectrometry, was developed for rapid identification of 24 flavonoid and naphthopyranone compounds. The methanol extracts of the capitulae and scapes of P. chiquitensis exhibited mutagenic activity in the Salmonella/microsome assay, against strain TA97a.
Keywords: Paepalanthus; naphthopyranones; flavonoids; mutagenicity Paepalanthus; naphthopyranones; flavonoids; mutagenicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Zanutto, F.V.; Boldrin, P.K.; Varanda, E.A.; Souza, S.F.; Sano, P.T.; Vilegas, W.; Santos, L.C. Characterization of Flavonoids and Naphthopyranones in Methanol Extracts of Paepalanthus chiquitensis Herzog by HPLC-ESI-IT-MSn and Their Mutagenic Activity. Molecules 2013, 18, 244-262.

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