Characterization of Flavonoids and Naphthopyranones in Methanol Extracts of Paepalanthus chiquitensis Herzog by HPLC-ESI-IT-MSn and Their Mutagenic Activity

doi:10.3390/molecules18010244

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Molecules 2013, 18(1), 244-262; doi:10.3390/molecules18010244

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Characterization of Flavonoids and Naphthopyranones in Methanol Extracts of Paepalanthus chiquitensis Herzog by HPLC-ESI-IT-MSⁿ and Their Mutagenic Activity

Fabiana Volpe Zanutto^1,2, Paula Karina Boldrin², Eliana Aparecida Varanda², Samara Fernandes de Souza¹, Paulo Takeo Sano³, Wagner Vilegas^1,4 and Lourdes Campaner dos Santos^1,*

¹ Department of Organic Chemistry, Institute of Chemistry, UNESP — Sao Paulo State University, Araraquara CEP 14800-900, Sao Paulo, Brazil ² Department of Biological Sciences, Faculty of Pharmaceutical Sciences of Araraquara, UNESP — Sao Paulo State University, Araraquara CEP 14801-902, Sao Paulo, Brazil ³ Institute of Biosciences, Sao Paulo University, Sao Paulo CEP 05508-900, Sao Paulo, Brazil ⁴ Experimental Campus of Sao Vicente, UNESP — Sao Paulo State University, Sao Vicente CEP 11350-000, Sao Paulo, Brazil

* Author to whom correspondence should be addressed.

Received: 28 November 2012; in revised form: 11 December 2012 / Accepted: 18 December 2012 / Published: 27 December 2012

(This article belongs to the Section Natural Products)

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Abstract: A HPLC-ESI-IT-MSⁿ method, based on high-performance liquid chromatography coupled to electrospray negative ionization multistage ion trap mass spectrometry, was developed for rapid identification of 24 flavonoid and naphthopyranone compounds. The methanol extracts of the capitulae and scapes of P. chiquitensis exhibited mutagenic activity in the Salmonella/microsome assay, against strain TA97a.

Keywords: Paepalanthus; naphthopyranones; flavonoids; mutagenicity

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MDPI and ACS Style

Zanutto, F.V.; Boldrin, P.K.; Varanda, E.A.; Souza, S.F.; Sano, P.T.; Vilegas, W.; Santos, L.C. Characterization of Flavonoids and Naphthopyranones in Methanol Extracts of Paepalanthus chiquitensis Herzog by HPLC-ESI-IT-MSⁿ and Their Mutagenic Activity. Molecules 2013, 18, 244-262.

AMA Style

Zanutto FV, Boldrin PK, Varanda EA, Souza SF, Sano PT, Vilegas W, Santos LC. Characterization of Flavonoids and Naphthopyranones in Methanol Extracts of Paepalanthus chiquitensis Herzog by HPLC-ESI-IT-MSⁿ and Their Mutagenic Activity. Molecules. 2013; 18(1):244-262.

Chicago/Turabian Style

Zanutto, Fabiana V.; Boldrin, Paula K.; Varanda, Eliana A.; Souza, Samara F.; Sano, Paulo T.; Vilegas, Wagner; Santos, Lourdes C. 2013. "Characterization of Flavonoids and Naphthopyranones in Methanol Extracts of Paepalanthus chiquitensis Herzog by HPLC-ESI-IT-MSⁿ and Their Mutagenic Activity." Molecules 18, no. 1: 244-262.

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