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Molecules 2013, 18(1), 128-139; doi:10.3390/molecules18010128
Article

Cytotoxic and Antioxidant Compoundsfrom the Stem Bark of Goniothalamus tapisoides Mat Salleh

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Received: 8 November 2012; in revised form: 16 December 2012 / Accepted: 19 December 2012 / Published: 21 December 2012
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Abstract: Eleven compounds:goniomicin A (1), goniomicin B (2), goniomicin C (3), goniomicin D (4), tapisoidin (5), goniothalamin (6), 9-deoxygoniopypyrone (7), pterodondiol (8), liriodenine (9), benzamide (10) and cinnamic acid (11), were isolated from the stem bark of Goniothalamus tapisoides. All compounds were identified by spectroscopic analysis and, for known compounds, by comparison with published data. Goniothalamin (6) exhibited mild cytotoxic activity towards a colon cancer cell line (HT-29), with an IC50value of 64.17 ± 5.60 µM. Goniomicin B (2) give the highest antioxidant activity in the DPPH assay among all compounds tested, with an IC50 of 0.207 µM.
Keywords: Goniothalamus tapisoides; goniomicins A–D; tapisoidin; cytotoxicity; antioxidant activity Goniothalamus tapisoides; goniomicins A–D; tapisoidin; cytotoxicity; antioxidant activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Kim, R.P.T.; Bihud, V.; bin Mohamad, K.; Leong, K.H.; bin Mohamad, J.; bin Ahmad, F.; Hazni, H.; Kasim, N.; Halim, S.N.A.; Awang, K. Cytotoxic and Antioxidant Compoundsfrom the Stem Bark of Goniothalamus tapisoides Mat Salleh. Molecules 2013, 18, 128-139.

AMA Style

Kim RPT, Bihud V, bin Mohamad K, Leong KH, bin Mohamad J, bin Ahmad F, Hazni H, Kasim N, Halim SNA, Awang K. Cytotoxic and Antioxidant Compoundsfrom the Stem Bark of Goniothalamus tapisoides Mat Salleh. Molecules. 2013; 18(1):128-139.

Chicago/Turabian Style

Kim, Rosalind P.T.; Bihud, Vicky; bin Mohamad, Khalit; Leong, Kok H.; bin Mohamad, Jamaludin; bin Ahmad, Fasihuddin; Hazni, Hazrina; Kasim, Noraini; Halim, Siti N.A.; Awang, Khalijah. 2013. "Cytotoxic and Antioxidant Compoundsfrom the Stem Bark of Goniothalamus tapisoides Mat Salleh." Molecules 18, no. 1: 128-139.


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