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Molecules 2013, 18(1), 128-139; doi:10.3390/molecules18010128

Cytotoxic and Antioxidant Compoundsfrom the Stem Bark of Goniothalamus tapisoides Mat Salleh

1
Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia
2
Faculty of Applied Sciences, MARA University of Technology, 40450 Shah Alam, Selangor, Malaysia
3
Department of Pharmacy, University of Malaya, 50603 Kuala Lumpur, Malaysia
4
Institute of Biological Sciences, Faculty of Sciences Building, University of Malaya, 50603 Kuala Lumpur, Malaysia
5
Faculty of Resource Science and Technology, Universiti Malaysia Sarawak, 94300 Kota Samarahan, Sarawak, Malaysia
*
Author to whom correspondence should be addressed.
Received: 8 November 2012 / Revised: 16 December 2012 / Accepted: 19 December 2012 / Published: 21 December 2012
Download PDF [309 KB, 18 June 2014; original version 18 June 2014]

Abstract

Eleven compounds:goniomicin A (1), goniomicin B (2), goniomicin C (3), goniomicin D (4), tapisoidin (5), goniothalamin (6), 9-deoxygoniopypyrone (7), pterodondiol (8), liriodenine (9), benzamide (10) and cinnamic acid (11), were isolated from the stem bark of Goniothalamus tapisoides. All compounds were identified by spectroscopic analysis and, for known compounds, by comparison with published data. Goniothalamin (6) exhibited mild cytotoxic activity towards a colon cancer cell line (HT-29), with an IC50value of 64.17 ± 5.60 µM. Goniomicin B (2) give the highest antioxidant activity in the DPPH assay among all compounds tested, with an IC50 of 0.207 µM.
Keywords: Goniothalamus tapisoides; goniomicins A–D; tapisoidin; cytotoxicity; antioxidant activity Goniothalamus tapisoides; goniomicins A–D; tapisoidin; cytotoxicity; antioxidant activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Kim, R.P.T.; Bihud, V.; bin Mohamad, K.; Leong, K.H.; bin Mohamad, J.; bin Ahmad, F.; Hazni, H.; Kasim, N.; Halim, S.N.A.; Awang, K. Cytotoxic and Antioxidant Compoundsfrom the Stem Bark of Goniothalamus tapisoides Mat Salleh. Molecules 2013, 18, 128-139.

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