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Molecules 2012, 17(9), 10928-10945; doi:10.3390/molecules170910928
Article

Systematic Study of the Physicochemical Properties of a Homologous Series of Aminobisphosphonates

1, 2, 3, 1, 1, 3, 1 and 1,*
1 School of Pharmacy, University of Eastern Finland, Biocenter Kuopio, P.O. Box 1627, FIN-70211 Kuopio, Finland 2 Laboratory of Inorganic Chemistry, Department of Chemistry, University of Helsinki, P.O. Box 55, FIN-00014 Helsinki, Finland 3 Department of Chemistry, University of Jyväskylä, P.O. Box 35, FIN-40014 Jyväskylä, Finland
* Author to whom correspondence should be addressed.
Received: 7 August 2012 / Revised: 4 September 2012 / Accepted: 5 September 2012 / Published: 12 September 2012
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Abstract

Aminobisphosphonates, e.g., alendronate and neridronate, are a well known class of molecules used as drugs for various bone diseases. Although these molecules have been available for decades, a detailed understanding of their most important physicochemical properties under comparable conditions is lacking. In this study, ten aminobisphosphonates, H2N(CH2)nC(OH)[P(O)(OH)2]2, in which n = 2–5, 7–11 and 15 have been synthesized. Their aqueous solubility as a function of temperature and pH, pKa-values, thermal stability, IR absorptions, and NMR spectral data for bothliquid (1H, 13C, 31P-NMR) and solid state (13C, 15N and 31P-CPMAS NMR) were determined.
Keywords: bisphosphonates; aqueous solubility; pKa; physicochemical properties bisphosphonates; aqueous solubility; pKa; physicochemical properties
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Alanne, A.-L.; Hyvönen, H.; Lahtinen, M.; Ylisirniö, M.; Turhanen, P.; Kolehmainen, E.; Peräniemi, S.; Vepsäläinen, J. Systematic Study of the Physicochemical Properties of a Homologous Series of Aminobisphosphonates. Molecules 2012, 17, 10928-10945.

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