Molecules 2012, 17(9), 10928-10945; doi:10.3390/molecules170910928
Article

Systematic Study of the Physicochemical Properties of a Homologous Series of Aminobisphosphonates

1, 2, 3, 1, 1, 3, 1 and 1,* email
Received: 7 August 2012; in revised form: 4 September 2012 / Accepted: 5 September 2012 / Published: 12 September 2012
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Aminobisphosphonates, e.g., alendronate and neridronate, are a well known class of molecules used as drugs for various bone diseases. Although these molecules have been available for decades, a detailed understanding of their most important physicochemical properties under comparable conditions is lacking. In this study, ten aminobisphosphonates, H2N(CH2)nC(OH)[P(O)(OH)2]2, in which n = 2–5, 7–11 and 15 have been synthesized. Their aqueous solubility as a function of temperature and pH, pKa-values, thermal stability, IR absorptions, and NMR spectral data for bothliquid (1H, 13C, 31P-NMR) and solid state (13C, 15N and 31P-CPMAS NMR) were determined.
Keywords: bisphosphonates; aqueous solubility; pKa; physicochemical properties
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MDPI and ACS Style

Alanne, A.-L.; Hyvönen, H.; Lahtinen, M.; Ylisirniö, M.; Turhanen, P.; Kolehmainen, E.; Peräniemi, S.; Vepsäläinen, J. Systematic Study of the Physicochemical Properties of a Homologous Series of Aminobisphosphonates. Molecules 2012, 17, 10928-10945.

AMA Style

Alanne A-L, Hyvönen H, Lahtinen M, Ylisirniö M, Turhanen P, Kolehmainen E, Peräniemi S, Vepsäläinen J. Systematic Study of the Physicochemical Properties of a Homologous Series of Aminobisphosphonates. Molecules. 2012; 17(9):10928-10945.

Chicago/Turabian Style

Alanne, Aino-Liisa; Hyvönen, Helena; Lahtinen, Manu; Ylisirniö, Markku; Turhanen, Petri; Kolehmainen, Erkki; Peräniemi, Sirpa; Vepsäläinen, Jouko. 2012. "Systematic Study of the Physicochemical Properties of a Homologous Series of Aminobisphosphonates." Molecules 17, no. 9: 10928-10945.

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