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Molecules 2012, 17(9), 10667-10674; doi:10.3390/molecules170910667

Synthesis and Protective Effect of Scutellarein on Focal Cerebral Ischemia/Reperfusion in Rats

1
Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine, Nanjing 210046, China
2
Department of Medicinal Chemistry, Nanjing University of Chinese Medicine, Nanjing 210046, China
*
Authors to whom correspondence should be addressed.
Received: 27 June 2012 / Revised: 13 August 2012 / Accepted: 28 August 2012 / Published: 6 September 2012
(This article belongs to the Section Medicinal Chemistry)
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Abstract

Scutellarein, the main metabolite of scutellarin in vivo, has relatively better solubility, bioavailability and bio-activity than scutellarin. However, compared with scutellarin, it is very difficult to obtain scutellarein from Nature. Therefore, the present study focused on establishing an efficient route for the synthesis of scutellarein by hydrolyzing scutellarin. Neurological deficit score and cerebral infarction volume with the administration of scutellarein were then used to compare its neuroprotective effects on focal cerebral ischemia/reperfusion in rats induced by middle cerebral artery occlusion (MCAO) with those of scutellarin. The results showed that scutellarein had better protective effect on focal cerebral ischemia/reperfusion than scutellarin, which laid the foundation for further research and development of scutellarein as a promising candidate for ischemic cerebro-vascular disease.
Keywords: scutellarein; scutellarin; synthesis; MCAO; focal cerebral ischemia/reperfusion scutellarein; scutellarin; synthesis; MCAO; focal cerebral ischemia/reperfusion
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Qian, L.; Shen, M.; Tang, H.; Tang, Y.; Zhang, L.; Fu, Y.; Shi, Q.; Li, N.-G. Synthesis and Protective Effect of Scutellarein on Focal Cerebral Ischemia/Reperfusion in Rats. Molecules 2012, 17, 10667-10674.

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