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Molecules 2012, 17(8), 9931-9938; doi:10.3390/molecules17089931
Article

The Bioassay-Guided Isolation of Growth Inhibitors of Adult T-Cell Leukemia (ATL), from the Jamaican Plant Hyptis verticillata, and NMR Characterization of Hyptoside

1,* , 2, 1, 1, 3, 1, 1 and 2
1 Graduate School of Science and Engineering, Kagoshima University, 1-21-35 Korimoto, Kagoshima 890-0065, Japan 2 Division of Hematology and Immunology, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan 3 Priority Organization for Innovation and Excellence, Kumamoto University, 5-1 Oe-Honmachi, Kumamoto 860-8555, Japan
* Author to whom correspondence should be addressed.
Received: 12 June 2012 / Revised: 7 August 2012 / Accepted: 8 August 2012 / Published: 17 August 2012
(This article belongs to the Section Metabolites)
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Abstract

Through bioassay-guided isolation, five compounds with growth inhibitory activity on S1T, an adult T-cell leukemia (ATL) cell line, were isolated from the crude methanol extract of the aerial parts of Hyptis verticillata.
Keywords: ATL; bioassay-guided isolation; S1T; growth inhibitor; lignan; NMR; structure ATL; bioassay-guided isolation; S1T; growth inhibitor; lignan; NMR; structure
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Hamada, T.; White, Y.; Nakashima, M.; Oiso, Y.; Fujita, M.J.; Okamura, H.; Iwagawa, T.; Arima, N. The Bioassay-Guided Isolation of Growth Inhibitors of Adult T-Cell Leukemia (ATL), from the Jamaican Plant Hyptis verticillata, and NMR Characterization of Hyptoside. Molecules 2012, 17, 9931-9938.

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