Molecules 2012, 17(8), 9931-9938; doi:10.3390/molecules17089931
Article

The Bioassay-Guided Isolation of Growth Inhibitors of Adult T-Cell Leukemia (ATL), from the Jamaican Plant Hyptis verticillata, and NMR Characterization of Hyptoside

Toshiyuki Hamada 1,* email, Yohann White 2 , Mitsuyoshi Nakashima 1 , Yusuke Oiso 1 , Masaki J. Fujita 3 , Hiroaki Okamura 1 , Tetsuo Iwagawa 1  and Naomichi Arima 2
1 Graduate School of Science and Engineering, Kagoshima University, 1-21-35 Korimoto, Kagoshima 890-0065, Japan 2 Division of Hematology and Immunology, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan 3 Priority Organization for Innovation and Excellence, Kumamoto University, 5-1 Oe-Honmachi, Kumamoto 860-8555, Japan
* Author to whom correspondence should be addressed.
Received: 12 June 2012; in revised form: 7 August 2012 / Accepted: 8 August 2012 / Published: 17 August 2012
(This article belongs to the Section Natural Products)
PDF Full-text Download PDF Full-Text [693 KB, Updated Version, uploaded 20 August 2012 10:42 CEST]
The original version is still available [693 KB, uploaded 17 August 2012 11:48 CEST]
Abstract: Through bioassay-guided isolation, five compounds with growth inhibitory activity on S1T, an adult T-cell leukemia (ATL) cell line, were isolated from the crude methanol extract of the aerial parts of Hyptis verticillata.
Keywords: ATL; bioassay-guided isolation; S1T; growth inhibitor; lignan; NMR; structure

Article Statistics

Click here to load and display the download statistics.

Cite This Article

MDPI and ACS Style

Hamada, T.; White, Y.; Nakashima, M.; Oiso, Y.; Fujita, M.J.; Okamura, H.; Iwagawa, T.; Arima, N. The Bioassay-Guided Isolation of Growth Inhibitors of Adult T-Cell Leukemia (ATL), from the Jamaican Plant Hyptis verticillata, and NMR Characterization of Hyptoside. Molecules 2012, 17, 9931-9938.

AMA Style

Hamada T, White Y, Nakashima M, Oiso Y, Fujita MJ, Okamura H, Iwagawa T, Arima N. The Bioassay-Guided Isolation of Growth Inhibitors of Adult T-Cell Leukemia (ATL), from the Jamaican Plant Hyptis verticillata, and NMR Characterization of Hyptoside. Molecules. 2012; 17(8):9931-9938.

Chicago/Turabian Style

Hamada, Toshiyuki; White, Yohann; Nakashima, Mitsuyoshi; Oiso, Yusuke; Fujita, Masaki J.; Okamura, Hiroaki; Iwagawa, Tetsuo; Arima, Naomichi. 2012. "The Bioassay-Guided Isolation of Growth Inhibitors of Adult T-Cell Leukemia (ATL), from the Jamaican Plant Hyptis verticillata, and NMR Characterization of Hyptoside." Molecules 17, no. 8: 9931-9938.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert