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Molecules 2012, 17(8), 9931-9938; doi:10.3390/molecules17089931
Article

The Bioassay-Guided Isolation of Growth Inhibitors of Adult T-Cell Leukemia (ATL), from the Jamaican Plant Hyptis verticillata, and NMR Characterization of Hyptoside

1,* , 2, 1, 1, 3, 1, 1 and 2
1 Graduate School of Science and Engineering, Kagoshima University, 1-21-35 Korimoto, Kagoshima 890-0065, Japan 2 Division of Hematology and Immunology, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan 3 Priority Organization for Innovation and Excellence, Kumamoto University, 5-1 Oe-Honmachi, Kumamoto 860-8555, Japan
* Author to whom correspondence should be addressed.
Received: 12 June 2012 / Revised: 7 August 2012 / Accepted: 8 August 2012 / Published: 17 August 2012
(This article belongs to the Section Natural Products)
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Abstract

Through bioassay-guided isolation, five compounds with growth inhibitory activity on S1T, an adult T-cell leukemia (ATL) cell line, were isolated from the crude methanol extract of the aerial parts of Hyptis verticillata.
Keywords: ATL; bioassay-guided isolation; S1T; growth inhibitor; lignan; NMR; structure ATL; bioassay-guided isolation; S1T; growth inhibitor; lignan; NMR; structure
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Hamada, T.; White, Y.; Nakashima, M.; Oiso, Y.; Fujita, M.J.; Okamura, H.; Iwagawa, T.; Arima, N. The Bioassay-Guided Isolation of Growth Inhibitors of Adult T-Cell Leukemia (ATL), from the Jamaican Plant Hyptis verticillata, and NMR Characterization of Hyptoside. Molecules 2012, 17, 9931-9938.

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