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Molecules 2012, 17(8), 9939-9946; doi:10.3390/molecules17089939

Article

Alkaloids Isolated from the Lateral Root of Aconitum carmichaelii

Liang Xiong ^1,2,3 , Cheng Peng ^1,2,3,* , Xiao-Fang Xie ^1,2,3 , Li Guo ^1,2,3 , Cheng-Jun He ^1,2,3 , Zhao Geng ^1,2,3 , Feng Wan ^1,2,3 , Ou Dai ^1,2,3  and Qin-Mei Zhou ^1,2,3

¹ State Key Laboratory Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, Sichuan Province and Ministry of Science and Technology, Chengdu 610075, Sichuan, China ² Key Laboratory of Standardization of Chinese Herbal Medicine, Ministry of Education, Chengdu 610075, Sichuan, China ³ Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan, China

* Author to whom correspondence should be addressed.

Received: 24 July 2012; in revised form: 31 July 2012 / Accepted: 3 August 2012 / Published: 20 August 2012

(This article belongs to the Section Natural Products)

Download PDF Full-Text [220 KB, Updated Version, uploaded 21 August 2012 08:50 CEST]

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Abstract: Two new alkaloids, aconicarmine (1) and aconicaramide (5), were isolated from the EtOH extract of the lateral roots of Aconitum carmichaelii, together with five known compounds: fuziline (2), neoline (3), N-ethylhokbusine B (4), 5-hydroxymethylpyrrole-2-carbaldehyde (6), and oleracein E (7). Their structures were elucidated by physical and NMR analysis. Pyrrole alkaloids were isolated from A. carmichaelii for the first time. In the in vitro assays, compounds 2 and 3 showed activity against pentobarbital sodium-induced cardiomyocytes damage by obviously recovering beating rhythm and increasing the cell viability, while compounds 5 and 7 showed moderate antibacterial activity.

Keywords: Aconitum carmichaelii; lateral root; alkaloids; bioactivities

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