Abstract: Two new alkaloids, aconicarmine (1) and aconicaramide (5), were isolated from the EtOH extract of the lateral roots of Aconitum carmichaelii, together with five known compounds: fuziline (2), neoline (3), N-ethylhokbusine B (4), 5-hydroxymethylpyrrole-2-carbaldehyde (6), and oleracein E (7). Their structures were elucidated by physical and NMR analysis. Pyrrole alkaloids were isolated from A. carmichaelii for the first time. In the in vitro assays, compounds 2 and 3 showed activity against pentobarbital sodium-induced cardiomyocytes damage by obviously recovering beating rhythm and increasing the cell viability, while compounds 5 and 7 showed moderate antibacterial activity.
Keywords: Aconitum carmichaelii; lateral root; alkaloids; bioactivities
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Xiong, L.; Peng, C.; Xie, X.-F.; Guo, L.; He, C.-J.; Geng, Z.; Wan, F.; Dai, O.; Zhou, Q.-M. Alkaloids Isolated from the Lateral Root of Aconitum carmichaelii. Molecules 2012, 17, 9939-9946.
Xiong L, Peng C, Xie X-F, Guo L, He C-J, Geng Z, Wan F, Dai O, Zhou Q-M. Alkaloids Isolated from the Lateral Root of Aconitum carmichaelii. Molecules. 2012; 17(8):9939-9946.
Xiong, Liang; Peng, Cheng; Xie, Xiao-Fang; Guo, Li; He, Cheng-Jun; Geng, Zhao; Wan, Feng; Dai, Ou; Zhou, Qin-Mei. 2012. "Alkaloids Isolated from the Lateral Root of Aconitum carmichaelii." Molecules 17, no. 8: 9939-9946.