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Molecules 2012, 17(8), 9939-9946; doi:10.3390/molecules17089939

Alkaloids Isolated from the Lateral Root of Aconitum carmichaelii

1,2,3,* , 1,2,3
1 State Key Laboratory Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, Sichuan Province and Ministry of Science and Technology, Chengdu 610075, Sichuan, China 2 Key Laboratory of Standardization of Chinese Herbal Medicine, Ministry of Education, Chengdu 610075, Sichuan, China 3 Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan, China
* Author to whom correspondence should be addressed.
Received: 24 July 2012 / Revised: 31 July 2012 / Accepted: 3 August 2012 / Published: 20 August 2012
(This article belongs to the Section Metabolites)
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Two new alkaloids, aconicarmine (1) and aconicaramide (5), were isolated from the EtOH extract of the lateral roots of Aconitum carmichaelii, together with five known compounds: fuziline (2), neoline (3), N-ethylhokbusine B (4), 5-hydroxymethylpyrrole-2-carbaldehyde (6), and oleracein E (7). Their structures were elucidated by physical and NMR analysis. Pyrrole alkaloids were isolated from A. carmichaelii for the first time. In the in vitro assays, compounds 2 and 3 showed activity against pentobarbital sodium-induced cardiomyocytes damage by obviously recovering beating rhythm and increasing the cell viability, while compounds 5 and 7 showed moderate antibacterial activity.
Keywords: Aconitum carmichaelii; lateral root; alkaloids; bioactivities Aconitum carmichaelii; lateral root; alkaloids; bioactivities
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Xiong, L.; Peng, C.; Xie, X.-F.; Guo, L.; He, C.-J.; Geng, Z.; Wan, F.; Dai, O.; Zhou, Q.-M. Alkaloids Isolated from the Lateral Root of Aconitum carmichaelii. Molecules 2012, 17, 9939-9946.

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