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Alkaloids Isolated from the Lateral Root of Aconitum carmichaelii
AbstractTwo new alkaloids, aconicarmine (1) and aconicaramide (5), were isolated from the EtOH extract of the lateral roots of Aconitum carmichaelii, together with five known compounds: fuziline (2), neoline (3), N-ethylhokbusine B (4), 5-hydroxymethylpyrrole-2-carbaldehyde (6), and oleracein E (7). Their structures were elucidated by physical and NMR analysis. Pyrrole alkaloids were isolated from A. carmichaelii for the first time. In the in vitro assays, compounds 2 and 3 showed activity against pentobarbital sodium-induced cardiomyocytes damage by obviously recovering beating rhythm and increasing the cell viability, while compounds 5 and 7 showed moderate antibacterial activity.
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Xiong, L.; Peng, C.; Xie, X.-F.; Guo, L.; He, C.-J.; Geng, Z.; Wan, F.; Dai, O.; Zhou, Q.-M. Alkaloids Isolated from the Lateral Root of Aconitum carmichaelii. Molecules 2012, 17, 9939-9946.View more citation formats
Xiong L, Peng C, Xie X-F, Guo L, He C-J, Geng Z, Wan F, Dai O, Zhou Q-M. Alkaloids Isolated from the Lateral Root of Aconitum carmichaelii. Molecules. 2012; 17(8):9939-9946.Chicago/Turabian Style
Xiong, Liang; Peng, Cheng; Xie, Xiao-Fang; Guo, Li; He, Cheng-Jun; Geng, Zhao; Wan, Feng; Dai, Ou; Zhou, Qin-Mei. 2012. "Alkaloids Isolated from the Lateral Root of Aconitum carmichaelii." Molecules 17, no. 8: 9939-9946.
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