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Molecules 2012, 17(8), 9939-9946; doi:10.3390/molecules17089939
Article

Alkaloids Isolated from the Lateral Root of Aconitum carmichaelii

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Received: 24 July 2012 / Revised: 31 July 2012 / Accepted: 3 August 2012 / Published: 20 August 2012
(This article belongs to the Section Metabolites)
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Abstract

Two new alkaloids, aconicarmine (1) and aconicaramide (5), were isolated from the EtOH extract of the lateral roots of Aconitum carmichaelii, together with five known compounds: fuziline (2), neoline (3), N-ethylhokbusine B (4), 5-hydroxymethylpyrrole-2-carbaldehyde (6), and oleracein E (7). Their structures were elucidated by physical and NMR analysis. Pyrrole alkaloids were isolated from A. carmichaelii for the first time. In the in vitro assays, compounds 2 and 3 showed activity against pentobarbital sodium-induced cardiomyocytes damage by obviously recovering beating rhythm and increasing the cell viability, while compounds 5 and 7 showed moderate antibacterial activity.
Keywords: Aconitum carmichaelii; lateral root; alkaloids; bioactivities Aconitum carmichaelii; lateral root; alkaloids; bioactivities
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Xiong, L.; Peng, C.; Xie, X.-F.; Guo, L.; He, C.-J.; Geng, Z.; Wan, F.; Dai, O.; Zhou, Q.-M. Alkaloids Isolated from the Lateral Root of Aconitum carmichaelii. Molecules 2012, 17, 9939-9946.

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