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Molecules 2012, 17(8), 9939-9946; doi:10.3390/molecules17089939
Article

Alkaloids Isolated from the Lateral Root of Aconitum carmichaelii

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1 State Key Laboratory Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, Sichuan Province and Ministry of Science and Technology, Chengdu 610075, Sichuan, China 2 Key Laboratory of Standardization of Chinese Herbal Medicine, Ministry of Education, Chengdu 610075, Sichuan, China 3 Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan, China
* Author to whom correspondence should be addressed.
Received: 24 July 2012 / Revised: 31 July 2012 / Accepted: 3 August 2012 / Published: 20 August 2012
(This article belongs to the Section Natural Products)
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Abstract

Two new alkaloids, aconicarmine (1) and aconicaramide (5), were isolated from the EtOH extract of the lateral roots of Aconitum carmichaelii, together with five known compounds: fuziline (2), neoline (3), N-ethylhokbusine B (4), 5-hydroxymethylpyrrole-2-carbaldehyde (6), and oleracein E (7). Their structures were elucidated by physical and NMR analysis. Pyrrole alkaloids were isolated from A. carmichaelii for the first time. In the in vitro assays, compounds 2 and 3 showed activity against pentobarbital sodium-induced cardiomyocytes damage by obviously recovering beating rhythm and increasing the cell viability, while compounds 5 and 7 showed moderate antibacterial activity.
Keywords: Aconitum carmichaelii; lateral root; alkaloids; bioactivities Aconitum carmichaelii; lateral root; alkaloids; bioactivities
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Xiong, L.; Peng, C.; Xie, X.-F.; Guo, L.; He, C.-J.; Geng, Z.; Wan, F.; Dai, O.; Zhou, Q.-M. Alkaloids Isolated from the Lateral Root of Aconitum carmichaelii. Molecules 2012, 17, 9939-9946.

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