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Molecules 2012, 17(8), 9835-9841; doi:10.3390/molecules17089835
Communication

Towards Recyclable NAD(P)H Regeneration Catalysts

1,†
,
2,‡
,
3
,
4,#
 and
3,*,*
1 Departamento de Química Orgánica, Universidad de Zaragoza, Pedro Cerbuna 12, E-50009, Spain 2 Department of Chemistry, Technische Universiät Berlin, Straße des 17, Juni 124, Berlin 10623, Germany 3 Department of Biotechnology, Delft University of Technology, Julianalaan 136, Delft 2628BL, The Netherlands 4 Freie Universität Berlin, Institute of Chemistry and Biochemistry, Takustraße 3, Berlin 14195, Germany Current address: Institute for Molecules and Materials, Radboud University, Heyendaalseweg 135, Nijmegen 6525 AJ, The Netherlands Current address: Molecular Design Institute and Department of Chemistry, New York University, 100 Washington Square East, New York, NY 10003, USA # Current address: Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario M5S 3H6, Canada
* Author to whom correspondence should be addressed.
Received: 14 June 2012 / Revised: 1 August 2012 / Accepted: 8 August 2012 / Published: 15 August 2012
(This article belongs to the Special Issue Enzyme-Catalyzed Reactions)
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Abstract

Rh(III)-TsDPEN, an immobilized analog of the well-known [Cp*Rh(bpy)(H2O)]2+ was evaluated as a heterogeneous, recyclable regeneration catalyst for reduced oxidoreductase cofactors [NAD(P)H]. Repeated use of this catalyst was established and the catalytic properties were initially investigated. Apparently, Rh(III)-TsDPEN is prone to severe diffusion limitations, necessitating further developments. Overall, a promising concept for chemoenzymatic redox catalysis is proposed, which may overcome some of the current limitations such as catalyst cost and incompatibility of Rh with some biocatalysts.
Keywords: biocatalysis; cofactor regeneration; chemoenzymatic cascades; immobilized catalysts biocatalysis; cofactor regeneration; chemoenzymatic cascades; immobilized catalysts
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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de Torres, M.; Dimroth, J.; Arends, I.W.C.E.; Keilitz, J.; Hollmann, F. Towards Recyclable NAD(P)H Regeneration Catalysts. Molecules 2012, 17, 9835-9841.

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