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Towards Recyclable NAD(P)H Regeneration Catalysts
Departamento de Química Orgánica, Universidad de Zaragoza, Pedro Cerbuna 12, E-50009, Spain
Department of Chemistry, Technische Universiät Berlin, Straße des 17, Juni 124, Berlin 10623, Germany
Department of Biotechnology, Delft University of Technology, Julianalaan 136, Delft 2628BL, The Netherlands
Freie Universität Berlin, Institute of Chemistry and Biochemistry, Takustraße 3, Berlin 14195, Germany
Current address: Institute for Molecules and Materials, Radboud University, Heyendaalseweg 135, Nijmegen 6525 AJ, The Netherlands
Current address: Molecular Design Institute and Department of Chemistry, New York University, 100 Washington Square East, New York, NY 10003, USA
Current address: Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario M5S 3H6, Canada
* Author to whom correspondence should be addressed.
Received: 14 June 2012; in revised form: 1 August 2012 / Accepted: 8 August 2012 / Published: 15 August 2012
Abstract: Rh(III)-TsDPEN, an immobilized analog of the well-known [Cp*Rh(bpy)(H2O)]2+ was evaluated as a heterogeneous, recyclable regeneration catalyst for reduced oxidoreductase cofactors [NAD(P)H]. Repeated use of this catalyst was established and the catalytic properties were initially investigated. Apparently, Rh(III)-TsDPEN is prone to severe diffusion limitations, necessitating further developments. Overall, a promising concept for chemoenzymatic redox catalysis is proposed, which may overcome some of the current limitations such as catalyst cost and incompatibility of Rh with some biocatalysts.
Keywords: biocatalysis; cofactor regeneration; chemoenzymatic cascades; immobilized catalysts
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de Torres, M.; Dimroth, J.; Arends, I.W.C.E.; Keilitz, J.; Hollmann, F. Towards Recyclable NAD(P)H Regeneration Catalysts. Molecules 2012, 17, 9835-9841.
de Torres M, Dimroth J, Arends IWCE, Keilitz J, Hollmann F. Towards Recyclable NAD(P)H Regeneration Catalysts. Molecules. 2012; 17(8):9835-9841.
de Torres, Miriam; Dimroth, Jonas; Arends, Isabel W. C. E.; Keilitz, Juliane; Hollmann, Frank. 2012. "Towards Recyclable NAD(P)H Regeneration Catalysts." Molecules 17, no. 8: 9835-9841.