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Molecules 2012, 17(8), 9835-9841; doi:10.3390/molecules17089835

Towards Recyclable NAD(P)H Regeneration Catalysts

1 Departamento de Química Orgánica, Universidad de Zaragoza, Pedro Cerbuna 12, E-50009, Spain 2 Department of Chemistry, Technische Universiät Berlin, Straße des 17, Juni 124, Berlin 10623, Germany 3 Department of Biotechnology, Delft University of Technology, Julianalaan 136, Delft 2628BL, The Netherlands 4 Freie Universität Berlin, Institute of Chemistry and Biochemistry, Takustraße 3, Berlin 14195, Germany Current address: Institute for Molecules and Materials, Radboud University, Heyendaalseweg 135, Nijmegen 6525 AJ, The Netherlands Current address: Molecular Design Institute and Department of Chemistry, New York University, 100 Washington Square East, New York, NY 10003, USA # Current address: Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario M5S 3H6, Canada
* Author to whom correspondence should be addressed.
Received: 14 June 2012 / Revised: 1 August 2012 / Accepted: 8 August 2012 / Published: 15 August 2012
(This article belongs to the Special Issue Enzyme-Catalyzed Reactions)
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Rh(III)-TsDPEN, an immobilized analog of the well-known [Cp*Rh(bpy)(H2O)]2+ was evaluated as a heterogeneous, recyclable regeneration catalyst for reduced oxidoreductase cofactors [NAD(P)H]. Repeated use of this catalyst was established and the catalytic properties were initially investigated. Apparently, Rh(III)-TsDPEN is prone to severe diffusion limitations, necessitating further developments. Overall, a promising concept for chemoenzymatic redox catalysis is proposed, which may overcome some of the current limitations such as catalyst cost and incompatibility of Rh with some biocatalysts.
Keywords: biocatalysis; cofactor regeneration; chemoenzymatic cascades; immobilized catalysts biocatalysis; cofactor regeneration; chemoenzymatic cascades; immobilized catalysts
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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de Torres, M.; Dimroth, J.; Arends, I.W.C.E.; Keilitz, J.; Hollmann, F. Towards Recyclable NAD(P)H Regeneration Catalysts. Molecules 2012, 17, 9835-9841.

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