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Diterpenoids from the Buds of Pinus banksiana Lamb.
Laboratoire d'analyse et de séparation des essences végétales, Département des sciences fondamentales, Chaire de recherche sur les agents anticancéreux d'origine naturelle, Université du Québec à Chicoutimi, Québec, G7H 2B1 Canada
* Author to whom correspondence should be addressed.
Received: 12 June 2012; in revised form: 5 August 2012 / Accepted: 10 August 2012 / Published: 13 August 2012
Abstract: Three new diterpenoids, namely 7α-hydroxyabieta-8,11,13,15-tetraen-18-oic acid, 7β,15,18-trihydroxyabieta-8,11,13-triene, 13,15-dihydroxypodocarpa-8,11,13-triene, and 12 other known compounds were isolated from buds of Pinus banksiana Lamb. All these compounds, except for 7-oxodehydroabietinol, were isolated for the first time from this plant. Their structures were elucidated by detailed spectroscopic studies and comparison with published data. All isolated compounds were tested for cytotoxic and antibacterial activities. Overall, two compounds, 7-oxodehydroabietinol and 18-nor-4,15-dihydroxyabieta-8,11,13-trien-7-one, showed moderate cytotoxicity against a human lung carcinoma cell line.
Keywords: Pinus banksiana; bud; dehydroabietane; cytotoxicity; antibacterial activity
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Georges, P.; Legault, J.; Lavoie, S.; Grenon, C.; Pichette, A. Diterpenoids from the Buds of Pinus banksiana Lamb.. Molecules 2012, 17, 9716-9727.
Georges P, Legault J, Lavoie S, Grenon C, Pichette A. Diterpenoids from the Buds of Pinus banksiana Lamb.. Molecules. 2012; 17(8):9716-9727.
Georges, Patricia; Legault, Jean; Lavoie, Serge; Grenon, Carole; Pichette, André. 2012. "Diterpenoids from the Buds of Pinus banksiana Lamb.." Molecules 17, no. 8: 9716-9727.