A Convenient Ultrasound-Promoted Synthesis of Some New Thiazole Derivatives Bearing a Coumarin Nucleus and Their Cytotoxic Activity
Abstract
:1. Introduction
2. Results and Discussion
2.1. Chemistry
2.2. In Vitro Cytotoxicity Assay
3. Experimental
3.1. Chemistry
3.1.1. General
3.1.2. Synthesis of 3-[1-(4-Substituted-5-(aryldiazenyl)thiazol-2-yl)hydrazono) ethyl]-2H-chromen-2-ones 5a–h
3.1.2.1. Method A: General Procedure
3.1.2.2. Method B
3.1.2.2.1. Synthesis of 3-[1-((4-Substituted thiazol-2-yl)hydrazono)ethyl]-2H-chromen-2-ones 8,9
3.1.2.2.2. Coupling of 8(9) with Arenediazonium Chlorides
3.1.3. Synthesis of 5-Arylidene-2-(2-(1-(2-oxo-2H-chromen-3-yl)ethylidene)hydrazinyl)thiazol-4(5H)-ones 10a–d
3.1.3.1. Method A
3.1.3.2. Method B
3.1.3.2.1. Synthesis of 2-[2-(1-(2-oxo-2H-chromen-3-yl)ethylidene)hydrazinyl]thiazol-4(5H)-one (11)
3.1.3.2.2. Reaction of 8 with Aromatic Aldehydes
3.1.4. Synthesis of 2-Cyano-N'-(1-(2-oxo-2H-chromen-3-yl)ethylidene)acetohydrazide (12)
3.1.5. Reaction of 11 with Aromatic Aldehydes
3.2. Cytotoxic Activity
4. Conclusions
Acknowledgements
References
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Gomha, S.M.; Khalil, K.D. A Convenient Ultrasound-Promoted Synthesis of Some New Thiazole Derivatives Bearing a Coumarin Nucleus and Their Cytotoxic Activity. Molecules 2012, 17, 9335-9347. https://doi.org/10.3390/molecules17089335
Gomha SM, Khalil KD. A Convenient Ultrasound-Promoted Synthesis of Some New Thiazole Derivatives Bearing a Coumarin Nucleus and Their Cytotoxic Activity. Molecules. 2012; 17(8):9335-9347. https://doi.org/10.3390/molecules17089335
Chicago/Turabian StyleGomha, Sobhi M., and Khaled D. Khalil. 2012. "A Convenient Ultrasound-Promoted Synthesis of Some New Thiazole Derivatives Bearing a Coumarin Nucleus and Their Cytotoxic Activity" Molecules 17, no. 8: 9335-9347. https://doi.org/10.3390/molecules17089335