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Molecules 2012, 17(8), 9321-9334; doi:10.3390/molecules17089321

Synthesis and Characterization of New Thiazolidinones Containing Coumarin Moieties and Their Antibacterial and Antioxidant Activities

1
College of Science and Arts at Ar-Rass, Qassim University, P.O. Box 53, Saudi Arabia
2
Laboratoire de chimie et physique quantiques, Université Paul Sabatier-Bât. 3R1b4, 118 route de Narbonne, 31062 Toulouse Cedex 09, France
*
Author to whom correspondence should be addressed.
Received: 18 June 2012 / Revised: 21 July 2012 / Accepted: 24 July 2012 / Published: 3 August 2012
(This article belongs to the Section Organic Synthesis)
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Abstract

New coumarin derivatives, namely (2-(4-methyl-2-oxo-2H-chromen-7-yloxy)-N-(4-oxo-2-phenylthiazolidin-3-yl)acetamide, N-(2-(3-methoxyphenyl)-4-oxothiazolidin-3-yl)-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)acetamide, 2-(4-methyl-2-oxo-2H-chromen-7-yloxy)-N-(4-oxo-2-(2,3,4trimethoxyphenyl)thiazolidin-3-yl)acetamide and N-(2-(4-bromophenyl)-4-oxothiazolidin-3-yl)-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)acetamide) were synthesized starting from 4-methyl-7-hydroxycoumarin. The structures of the obtained compounds were confirmed by analytical IR and NMR spectra to elucidate the different positions of protons and carbons and as well as theoretical studies (DFT/B3LYP). The new compounds were screened for antibacterial activity. Most of them are more active against E. coli S. aureus and B. subtilis than standard references.
Keywords: coumarin; ethyl bromoacetate; thiazolidinones; DFT studies; antibacterial activities coumarin; ethyl bromoacetate; thiazolidinones; DFT studies; antibacterial activities
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Hamdi, N.; Al-Ayed, A.S.; Ben Said, R.; Fabienne, A. Synthesis and Characterization of New Thiazolidinones Containing Coumarin Moieties and Their Antibacterial and Antioxidant Activities. Molecules 2012, 17, 9321-9334.

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