Molecules 2012, 17(8), 9321-9334; doi:10.3390/molecules17089321
Article

Synthesis and Characterization of New Thiazolidinones Containing Coumarin Moieties and Their Antibacterial and Antioxidant Activities

1,* email, 1, 1 and 2
Received: 18 June 2012; in revised form: 21 July 2012 / Accepted: 24 July 2012 / Published: 3 August 2012
(This article belongs to the Section Organic Synthesis)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: New coumarin derivatives, namely (2-(4-methyl-2-oxo-2H-chromen-7-yloxy)-N-(4-oxo-2-phenylthiazolidin-3-yl)acetamide, N-(2-(3-methoxyphenyl)-4-oxothiazolidin-3-yl)-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)acetamide, 2-(4-methyl-2-oxo-2H-chromen-7-yloxy)-N-(4-oxo-2-(2,3,4trimethoxyphenyl)thiazolidin-3-yl)acetamide and N-(2-(4-bromophenyl)-4-oxothiazolidin-3-yl)-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)acetamide) were synthesized starting from 4-methyl-7-hydroxycoumarin. The structures of the obtained compounds were confirmed by analytical IR and NMR spectra to elucidate the different positions of protons and carbons and as well as theoretical studies (DFT/B3LYP). The new compounds were screened for antibacterial activity. Most of them are more active against E. coli S. aureus and B. subtilis than standard references.
Keywords: coumarin; ethyl bromoacetate; thiazolidinones; DFT studies; antibacterial activities
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MDPI and ACS Style

Hamdi, N.; Al-Ayed, A.S.; Ben Said, R.; Fabienne, A. Synthesis and Characterization of New Thiazolidinones Containing Coumarin Moieties and Their Antibacterial and Antioxidant Activities. Molecules 2012, 17, 9321-9334.

AMA Style

Hamdi N, Al-Ayed AS, Ben Said R, Fabienne A. Synthesis and Characterization of New Thiazolidinones Containing Coumarin Moieties and Their Antibacterial and Antioxidant Activities. Molecules. 2012; 17(8):9321-9334.

Chicago/Turabian Style

Hamdi, Naceur; Al-Ayed, Abdullah Sulaiman; Ben Said, Ridha; Fabienne, Alary. 2012. "Synthesis and Characterization of New Thiazolidinones Containing Coumarin Moieties and Their Antibacterial and Antioxidant Activities." Molecules 17, no. 8: 9321-9334.

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