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Molecules 2012, 17(8), 9321-9334; doi:10.3390/molecules17089321
Article

Synthesis and Characterization of New Thiazolidinones Containing Coumarin Moieties and Their Antibacterial and Antioxidant Activities

1,* , 1, 1 and 2
1 College of Science and Arts at Ar-Rass, Qassim University, P.O. Box 53, Saudi Arabia 2 Laboratoire de chimie et physique quantiques, Université Paul Sabatier-Bât. 3R1b4, 118 route de Narbonne, 31062 Toulouse Cedex 09, France
* Author to whom correspondence should be addressed.
Received: 18 June 2012 / Revised: 21 July 2012 / Accepted: 24 July 2012 / Published: 3 August 2012
(This article belongs to the Section Organic Synthesis)
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Abstract

New coumarin derivatives, namely (2-(4-methyl-2-oxo-2H-chromen-7-yloxy)-N-(4-oxo-2-phenylthiazolidin-3-yl)acetamide, N-(2-(3-methoxyphenyl)-4-oxothiazolidin-3-yl)-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)acetamide, 2-(4-methyl-2-oxo-2H-chromen-7-yloxy)-N-(4-oxo-2-(2,3,4trimethoxyphenyl)thiazolidin-3-yl)acetamide and N-(2-(4-bromophenyl)-4-oxothiazolidin-3-yl)-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)acetamide) were synthesized starting from 4-methyl-7-hydroxycoumarin. The structures of the obtained compounds were confirmed by analytical IR and NMR spectra to elucidate the different positions of protons and carbons and as well as theoretical studies (DFT/B3LYP). The new compounds were screened for antibacterial activity. Most of them are more active against E. coli S. aureus and B. subtilis than standard references.
Keywords: coumarin; ethyl bromoacetate; thiazolidinones; DFT studies; antibacterial activities coumarin; ethyl bromoacetate; thiazolidinones; DFT studies; antibacterial activities
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Hamdi, N.; Al-Ayed, A.S.; Ben Said, R.; Fabienne, A. Synthesis and Characterization of New Thiazolidinones Containing Coumarin Moieties and Their Antibacterial and Antioxidant Activities. Molecules 2012, 17, 9321-9334.

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