Cyclization-Carbonylation-Cyclization Coupling Reaction of Propargyl Ureas with Palladium(II)-Bisoxazoline Catalyst

doi:10.3390/molecules17089220

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Molecules 2012, 17(8), 9220-9230; doi:10.3390/molecules17089220

Article

Cyclization-Carbonylation-Cyclization Coupling Reaction of Propargyl Ureas with Palladium(II)-Bisoxazoline Catalyst

Taichi Kusakabe¹, Koujiro Kawaguchi¹, Miya Kawamura¹, Naohiko Niimura¹, Rong Shen¹, Hiroyuki Takayama^2,* and Keisuke Kato^1,*

¹ Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan ² School of Pharmacy, Nihon Pharmaceutical University, 10281, Komuro, Inamachi, Kita-Adachigun, Saitama 362-0806, Japan

* Authors to whom correspondence should be addressed.

Received: 16 July 2012; in revised form: 30 July 2012 / Accepted: 31 July 2012 / Published: 2 August 2012

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Abstract: The cyclization-carbonylation-cyclization coupling reaction (CCC-coupling reaction) of propargyl ureas catalyzed by Pd^II(box) complexes afforded symmetrical ketones bearing two 2-amino-2-oxazoline groups in good to moderate yields.

Keywords: CCC-coupling; bisoxazoline; palladium; carbonylation; propargyl urea

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Cite This Article

MDPI and ACS Style

Kusakabe, T.; Kawaguchi, K.; Kawamura, M.; Niimura, N.; Shen, R.; Takayama, H.; Kato, K. Cyclization-Carbonylation-Cyclization Coupling Reaction of Propargyl Ureas with Palladium(II)-Bisoxazoline Catalyst. Molecules 2012, 17, 9220-9230.

AMA Style

Kusakabe T, Kawaguchi K, Kawamura M, Niimura N, Shen R, Takayama H, Kato K. Cyclization-Carbonylation-Cyclization Coupling Reaction of Propargyl Ureas with Palladium(II)-Bisoxazoline Catalyst. Molecules. 2012; 17(8):9220-9230.

Chicago/Turabian Style

Kusakabe, Taichi; Kawaguchi, Koujiro; Kawamura, Miya; Niimura, Naohiko; Shen, Rong; Takayama, Hiroyuki; Kato, Keisuke. 2012. "Cyclization-Carbonylation-Cyclization Coupling Reaction of Propargyl Ureas with Palladium(II)-Bisoxazoline Catalyst." Molecules 17, no. 8: 9220-9230.

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