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Molecules 2012, 17(8), 8928-8937; doi:10.3390/molecules17088928

Anti-Platelet Aggregation and Vasorelaxing Effects of the Constituents of the Rhizomes of Zingiber officinale

1 Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan 2 Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan 3 Department of Biotechnology, Southern Taiwan University, Tainan 710, Taiwan 4 Department of Biotechnology, National Formosa University, Yunlin 632, Taiwan 5 Department of Pharmacy, China Medical University, Taichung 404, Taiwan 6 Chinese Medicinal Research and Development Center, China Medical University and Hospital, Taichung 404, Taiwan
* Author to whom correspondence should be addressed.
Received: 10 May 2012 / Revised: 13 July 2012 / Accepted: 21 July 2012 / Published: 26 July 2012
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In the present study, the chemical investigation of the bioactive fractions of the rhizomes of Zingiber officinale has resulted in the identification of twenty-nine compounds including one new compound, O-methyldehydrogingerol (1). Some of the isolates were subjected into the evaluation of their antiplatelet aggregation and vasorelaxing bioactivities. Among the tested compounds, [6]-gingerol (13) and [6]-shogaol (17) exhibited potent anti-platelet aggregation bioactivity. In addition, [10]-gingerol (15) inhibited the Ca2+-dependent contractions in high K+ medium. According to the results in the present research, the bioactivity of ginger could be related to the anti-platelet aggregation and vasorelaxing mechanism.
Keywords: anti-platelet aggregation; vasorelaxing; Zingiberaceae; gingerol; shogaol anti-platelet aggregation; vasorelaxing; Zingiberaceae; gingerol; shogaol
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Liao, Y.-R.; Leu, Y.-L.; Chan, Y.-Y.; Kuo, P.-C.; Wu, T.-S. Anti-Platelet Aggregation and Vasorelaxing Effects of the Constituents of the Rhizomes of Zingiber officinale. Molecules 2012, 17, 8928-8937.

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