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Molecules 2012, 17(8), 8928-8937; doi:10.3390/molecules17088928

Anti-Platelet Aggregation and Vasorelaxing Effects of the Constituents of the Rhizomes of Zingiber officinale

1 Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan 2 Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan 3 Department of Biotechnology, Southern Taiwan University, Tainan 710, Taiwan 4 Department of Biotechnology, National Formosa University, Yunlin 632, Taiwan 5 Department of Pharmacy, China Medical University, Taichung 404, Taiwan 6 Chinese Medicinal Research and Development Center, China Medical University and Hospital, Taichung 404, Taiwan
* Author to whom correspondence should be addressed.
Received: 10 May 2012 / Revised: 13 July 2012 / Accepted: 21 July 2012 / Published: 26 July 2012
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In the present study, the chemical investigation of the bioactive fractions of the rhizomes of Zingiber officinale has resulted in the identification of twenty-nine compounds including one new compound, O-methyldehydrogingerol (1). Some of the isolates were subjected into the evaluation of their antiplatelet aggregation and vasorelaxing bioactivities. Among the tested compounds, [6]-gingerol (13) and [6]-shogaol (17) exhibited potent anti-platelet aggregation bioactivity. In addition, [10]-gingerol (15) inhibited the Ca2+-dependent contractions in high K+ medium. According to the results in the present research, the bioactivity of ginger could be related to the anti-platelet aggregation and vasorelaxing mechanism.
Keywords: anti-platelet aggregation; vasorelaxing; Zingiberaceae; gingerol; shogaol anti-platelet aggregation; vasorelaxing; Zingiberaceae; gingerol; shogaol
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Liao, Y.-R.; Leu, Y.-L.; Chan, Y.-Y.; Kuo, P.-C.; Wu, T.-S. Anti-Platelet Aggregation and Vasorelaxing Effects of the Constituents of the Rhizomes of Zingiber officinale. Molecules 2012, 17, 8928-8937.

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