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Molecules 2012, 17(8), 8917-8927; doi:10.3390/molecules17088917

Gastroprotection of Suaveolol, Isolated from Hyptis suaveolens, against Ethanol-Induced Gastric Lesions in Wistar Rats: Role of Prostaglandins, Nitric Oxide and Sulfhydryls

1 Superior Medicine School, National Polytechnic Institute, Plan de San Luis y Díaz Mirón, Colonia Santo Tomás, Delegación Miguel Hidalgo, Mexico City, 11340, Mexico 2 Zaragoza Faculty of Higher Studies, Batalla del 5 de Mayo Esquina Fuerte de Loreto, Ejército de Oriente, Mexico City, 09230, Mexico 3 Technological University of the Jungle, Entronque Toniná Carretera Ocosingo-Altamirano, Ocosingo, State of Chiapas, 29950, Mexico
* Author to whom correspondence should be addressed.
Received: 13 June 2012 / Revised: 20 July 2012 / Accepted: 23 July 2012 / Published: 26 July 2012
(This article belongs to the Section Natural Products)
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Hyptis suaveolens is a medicinal plant that is, according to traditional medicine, considered useful in the treatment of gastric ulcers. Although its gastroprotective activity was reported, the active compounds have not been identified. Therefore, the aim of the present study was to identify at least one active compound potentially responsible for the gastroprotective activity of H. suaveolens by using a bioassay guided study with an ethanol-induced gastric ulcer experimental model in rats. The results show that the hexane extract had protective activity (close to 70% when using doses between 10 and 100 mg/kg), and that the compound suaveolol, isolated from this extract, was one of the active gastroprotective agents. This is the first report about the gastroprotective activity of suaveolol. Rats treated with this compound at 3, 10, 30 and 100 mg/kg showed 12.6, 21.3, 39.6 and 70.2% gastroprotection respectively. The effect elicited by suaveolol (at 100 mg/kg) was attenuated by pretreatment with either NG-nitro-L-arginine methyl ester (70 mg/kg, i.p.), a nitric oxide (NO) synthase inhibitor, indomethacin (10 mg/kg, s.c.), a blocker of prostaglandin synthesis, or N-ethylmaleimide (10 mg/kg, s.c.), a blocker of sulfhydryl groups. This suggests that the gastroprotective mechanism of action of this compound involves NO, prostaglandins and sulfhydryl groups.
Keywords: Hyptis suaveolens; suaveolol; gastroprotection; medicinal plants Hyptis suaveolens; suaveolol; gastroprotection; medicinal plants
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Vera-Arzave, C.; Antonio, L.C.; Arrieta, J.; Cruz-Hernández, G.; Velázquez-Méndez, A.M.; Reyes-Ramírez, A.; Sánchez-Mendoza, M.E. Gastroprotection of Suaveolol, Isolated from Hyptis suaveolens, against Ethanol-Induced Gastric Lesions in Wistar Rats: Role of Prostaglandins, Nitric Oxide and Sulfhydryls. Molecules 2012, 17, 8917-8927.

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