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Molecules 2012, 17(8), 8898-8907; doi:10.3390/molecules17088898

The Photodegradation of Quercetin: Relation to Oxidation

*  and
Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via F. Marzolo 5, 35131 Padova, Italy
* Author to whom correspondence should be addressed.
Received: 2 May 2012 / Revised: 13 July 2012 / Accepted: 21 July 2012 / Published: 26 July 2012
(This article belongs to the Section Natural Products)
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The photostability of quercetin in alcoholic solutions was studied. Both UVA and UVB light induced degradation of quercetin, yielding a single product 1 deriving from oxidation and addition of an alcohol molecule to the 2,3 double bond. The same mechanism operated when quercetin was dissolved in alkaline solutions, and again a product 2 due to oxidation and addition of water was characterized. Comparison with quercetin analogs confirmed that, despite the presence of five hydroxy groups in quercetin, those in positions 3, 3′, and 4′ are mainly involved in the antioxidant activity of the compound , as well as in its photolability.
Keywords: quercetin; photostability; photodegradation quercetin; photostability; photodegradation
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Dall’Acqua, S.; Miolo, G.; Innocenti, G.; Caffieri, S. The Photodegradation of Quercetin: Relation to Oxidation. Molecules 2012, 17, 8898-8907.

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