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Molecules 2012, 17(8), 8886-8897; doi:10.3390/molecules17088886
Article

Protective Effect of Polyphenols Extract of Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) on Hypercholesterolemia-Induced Oxidative Stress in Rats

1,2
, 3
, 2
, 2
 and 1,2,*
1 School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 24122, China 2 School of Food Science and Engineering, Nanjing University of Finance and Economics, Nanjing, Jiangsu 210046, China 3 Key Laboratory of Functional Dairy, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China
* Author to whom correspondence should be addressed.
Received: 11 June 2012 / Revised: 15 July 2012 / Accepted: 21 July 2012 / Published: 26 July 2012
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Abstract

The present study examines the effect of polyphenols extract of adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) (APE) on high cholesterol diet fed rats (HCD). APE was orally administrated by gavage at doses of 10, 40 and 200 mg total phenolics/kg body weight of rats once a day for 28 days. At the end of four weeks, serum triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C), and markers of oxidative stress viz., malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) in the serum and liver of HCD and normal rats were assessed and compared. The results showed that administration of APE was significantly effective in decreasing the serum levels of TC, LDL-C and MDA, increasing the serum level of HDL-C and antioxidant capacity. In addition, oral gavage of APE could also increase the antioxidant capacity, CAT and GSH-Px activities in liver. These results suggested that APE exerted a high hypocholesterolemic and antioxidant activities, which might be characterized by a protective effect on cardiovascular health in vivo.
Keywords: adlay; polyphenols; hypercholesterolemia; lipid peroxidation; antioxidant enzymes adlay; polyphenols; hypercholesterolemia; lipid peroxidation; antioxidant enzymes
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Wang, L.; Sun, J.; Yi, Q.; Wang, X.; Ju, X. Protective Effect of Polyphenols Extract of Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) on Hypercholesterolemia-Induced Oxidative Stress in Rats. Molecules 2012, 17, 8886-8897.

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