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Molecules 2012, 17(8), 8851-8858; doi:10.3390/molecules17088851

An ent-Kaurane-Type Diterpene in Croton antisyphiliticus Mart.

, , , , ,  and *
Department of Biotechnology, University of Ribeirão Preto (UNAERP), Av. Costábile Romano, 2201, CEP 14096-900, Ribeirão Preto, SP, Brazil
* Author to whom correspondence should be addressed.
Received: 9 May 2012 / Revised: 13 June 2012 / Accepted: 16 July 2012 / Published: 25 July 2012
(This article belongs to the Section Natural Products)
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Croton antisyphiliticus is a medicinal plant widely used in the treatment of microbial infections, especially those affecting the genital tract. Crude extract, fractions and pure compound isolated from roots of this species were investigated to validate their antimicrobial activity against Escherichia coli and Staphylococcus aureus. The compound ent-kaur-16-en-18-oic acid was isolated as a major component (0.7% of crude extract), and its MIC value determined against S. aureus (ATCC 6538) was 250 μg/mL. This is the first phytochemical work on the species monitored with antimicrobial assay.
Keywords: diterpene; Euphorbiaceae; antibacterial; Cerrado diterpene; Euphorbiaceae; antibacterial; Cerrado
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Pereira, S.; Taleb-Contini, S.; Coppede, J.; Pereira, P.; Bertoni, B.; França, S.; Pereira, A.M. An ent-Kaurane-Type Diterpene in Croton antisyphiliticus Mart.. Molecules 2012, 17, 8851-8858.

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