Abstract: The present study was undertaken to investigate the anti-inflammatory and analgesic activity of total flavone of branches and leaves of Cunninghamia lanceolata (TFC) to provide a scientific basis for its clinical use and resource development. TFC was evaluated for anti-inflammatory and analgesic activity in mice or rats using chemical and thermal models of nociception, including acetic acid-induced writhing test, hot plate latency test, formalin test and carrageenan induced paw oedema test. Results showed that TFC given orally can significantly attenuate acetic acid-induced writhing in mice in a dose-dependent manner. In the hot plate latency test, TFC showed common activity in prolonging duration time only at the highest dose (400 mg/kg). Each dose of TFC could not significantly inhibit the first phase but was active in the later phase of formalin-induced pain, whereas morphine showed notable activity in the two phases. In the carrageenan-induced paw oedema model, TFC could significantly and dose-dependently reduce the carrageenan-induced paw edema at the third and fifth hour, and decrease the content of PEG2 in paw edema tissue and that of COX-2 in blood serum. It may be concluded that TFC showed both anti-inflammatory and analgesic effects, showing that it can be of importance in drug development, especially in the field of pain and inflammation.
Keywords: Cunninghamia lanceolata (Lamb.) Hook; total flavone; anti-inflammatory; analgesia
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Xin, H.-L.; Zhai, X.-F.; Zheng, X.; Zhang, L.; Wang, Y.-L.; Wang, Z. Anti-Inflammatory and Analgesic Activity of Total Flavone of Cunninghamia lanceolata. Molecules 2012, 17, 8842-8850.
Xin H-L, Zhai X-F, Zheng X, Zhang L, Wang Y-L, Wang Z. Anti-Inflammatory and Analgesic Activity of Total Flavone of Cunninghamia lanceolata. Molecules. 2012; 17(8):8842-8850.
Xin, Hai-Liang; Zhai, Xiao-Feng; Zheng, Xu; Zhang, Lei; Wang, Yu-Liang; Wang, Zhuo. 2012. "Anti-Inflammatory and Analgesic Activity of Total Flavone of Cunninghamia lanceolata." Molecules 17, no. 8: 8842-8850.