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Molecules 2012, 17(8), 8842-8850; doi:10.3390/molecules17088842
Article

Anti-Inflammatory and Analgesic Activity of Total Flavone of Cunninghamia lanceolata

1, 1, 2, 3, 4,*  and 5,*
1 Department of Traditional Chinese Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433, China 2 Department of Naval Medicine, Second Military Medical University, Shanghai 200433, China 3 Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China 4 Plant Biotechnology Research Center, School of Agriculture and Biology, Fudan-SJTU-Nottingham Plant Biotechnology R&D Center, Shanghai Jiao Tong University, Shanghai 200240, China 5 Department of Pharmacy, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
* Authors to whom correspondence should be addressed.
Received: 21 May 2012 / Revised: 9 July 2012 / Accepted: 13 July 2012 / Published: 25 July 2012
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Abstract

The present study was undertaken to investigate the anti-inflammatory and analgesic activity of total flavone of branches and leaves of Cunninghamia lanceolata (TFC) to provide a scientific basis for its clinical use and resource development. TFC was evaluated for anti-inflammatory and analgesic activity in mice or rats using chemical and thermal models of nociception, including acetic acid-induced writhing test, hot plate latency test, formalin test and carrageenan induced paw oedema test. Results showed that TFC given orally can significantly attenuate acetic acid-induced writhing in mice in a dose-dependent manner. In the hot plate latency test, TFC showed common activity in prolonging duration time only at the highest dose (400 mg/kg). Each dose of TFC could not significantly inhibit the first phase but was active in the later phase of formalin-induced pain, whereas morphine showed notable activity in the two phases. In the carrageenan-induced paw oedema model, TFC could significantly and dose-dependently reduce the carrageenan-induced paw edema at the third and fifth hour, and decrease the content of PEG2 in paw edema tissue and that of COX-2 in blood serum. It may be concluded that TFC showed both anti-inflammatory and analgesic effects, showing that it can be of importance in drug development, especially in the field of pain and inflammation.
Keywords: Cunninghamia lanceolata (Lamb.) Hook; total flavone; anti-inflammatory; analgesia Cunninghamia lanceolata (Lamb.) Hook; total flavone; anti-inflammatory; analgesia
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Xin, H.-L.; Zhai, X.-F.; Zheng, X.; Zhang, L.; Wang, Y.-L.; Wang, Z. Anti-Inflammatory and Analgesic Activity of Total Flavone of Cunninghamia lanceolata. Molecules 2012, 17, 8842-8850.

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