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Molecules 2012, 17(7), 8554-8560; doi:10.3390/molecules17078554

Two New Oxysporone Derivatives from the Fermentation Broth of the Endophytic Plant Fungus Pestalotiopsis karstenii Isolated from Stems of Camellia sasanqua

1
Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Baoding 071002, China
2
College of Life Science, Hebei University, Baoding 071002, China
*
Author to whom correspondence should be addressed.
Received: 5 June 2012 / Revised: 30 June 2012 / Accepted: 5 July 2012 / Published: 17 July 2012
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Abstract

Two new oxysporone derivatives, pestalrone A (1) and pestalrone B (2), along with two known structurally related compounds 3,4, were from the fermentation broth of the endophytic plant fungus Pestalotiopsis karstenii isolated from stems of Camellia sasanqua. Their structures and relative configurations were elucidated by extensive spectroscopic analysis and comparison of chemical shifts with related known compounds. Compound 2 exhibited significant activities agains HeLa, HepG2 and U-251 with IC50 values of 12.6, 31.7 and 5.4 µg/mL, respectively.
Keywords: Pestalotiopsis karstenii; secondary metabolites; pestalrone A; pestalrone B Pestalotiopsis karstenii; secondary metabolites; pestalrone A; pestalrone B
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Luo, D.Q.; Zhang, L.; Shi, B.Z.; Song, X.M. Two New Oxysporone Derivatives from the Fermentation Broth of the Endophytic Plant Fungus Pestalotiopsis karstenii Isolated from Stems of Camellia sasanqua. Molecules 2012, 17, 8554-8560.

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