Two New Oxysporone Derivatives from the Fermentation Broth of the Endophytic Plant Fungus Pestalotiopsis karstenii Isolated from Stems of Camellia sasanqua

doi:10.3390/molecules17078554

This article is

freely available
re-usable

Molecules 2012, 17(7), 8554-8560; doi:10.3390/molecules17078554

Article

Two New Oxysporone Derivatives from the Fermentation Broth of the Endophytic Plant Fungus Pestalotiopsis karstenii Isolated from Stems of Camellia sasanqua

Du Qiang Luo^1,2,* , Lei Zhang^1,2, Bao Zhong Shi² and Xiao Mei Song¹

¹ Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Baoding 071002, China ² College of Life Science, Hebei University, Baoding 071002, China

* Author to whom correspondence should be addressed.

Received: 5 June 2012; in revised form: 30 June 2012 / Accepted: 5 July 2012 / Published: 17 July 2012

Download PDF Full-Text [198 KB, uploaded 17 July 2012 08:09 CEST]

Abstract: Two new oxysporone derivatives, pestalrone A (1) and pestalrone B (2), along with two known structurally related compounds 3,4, were from the fermentation broth of the endophytic plant fungus Pestalotiopsis karstenii isolated from stems of Camellia sasanqua. Their structures and relative configurations were elucidated by extensive spectroscopic analysis and comparison of chemical shifts with related known compounds. Compound 2 exhibited significant activities agains HeLa, HepG2 and U-251 with IC₅₀ values of 12.6, 31.7 and 5.4 µg/mL, respectively.

Keywords: Pestalotiopsis karstenii; secondary metabolites; pestalrone A; pestalrone B

Supplementary Files

Supplementary File 1:
PDF-Document (PDF, 2431 KB)

Article Statistics

Click here to load and display the download statistics.

Cite This Article

MDPI and ACS Style

Luo, D.Q.; Zhang, L.; Shi, B.Z.; Song, X.M. Two New Oxysporone Derivatives from the Fermentation Broth of the Endophytic Plant Fungus Pestalotiopsis karstenii Isolated from Stems of Camellia sasanqua. Molecules 2012, 17, 8554-8560.

AMA Style

Luo DQ, Zhang L, Shi BZ, Song XM. Two New Oxysporone Derivatives from the Fermentation Broth of the Endophytic Plant Fungus Pestalotiopsis karstenii Isolated from Stems of Camellia sasanqua. Molecules. 2012; 17(7):8554-8560.

Chicago/Turabian Style

Luo, Du Qiang; Zhang, Lei; Shi, Bao Zhong; Song, Xiao Mei. 2012. "Two New Oxysporone Derivatives from the Fermentation Broth of the Endophytic Plant Fungus Pestalotiopsis karstenii Isolated from Stems of Camellia sasanqua." Molecules 17, no. 7: 8554-8560.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert