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Molecules 2012, 17(7), 8518-8532; doi:10.3390/molecules17078518
Article

Preparation and Preliminary Biological Evaluation of Novel 99mTc-Labelled Thymidine Analogs as Tumor Imaging Agents

1,2,* , 1, 1, 1 and 1
1 Key Laboratory of Nuclear Medicine, Ministry of Health-Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China 2 School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China
* Author to whom correspondence should be addressed.
Received: 18 May 2012 / Revised: 27 June 2012 / Accepted: 5 July 2012 / Published: 16 July 2012
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Abstract

Two kinds of novel thymidine derivatives, N-thymidine-yl-N′-methyl-N′-{N′′-[2-sulfanyl-(ethylamino)acetyl]-2-aminoethylsulfanyl-1-hexanamide}-ethanediamine (TMHEA) and N-thymidine-yl-N′-methyl-N′-{N′′-[2-sulfanyl-(ethylamino)acetyl]-2-aminoethylsulfanyl-1-hexanamide}-hexanediamine (TMHHA) were prepared and successfully labeled with 99mTc in high labeling yields. The in vitro stability and in vivo biodistribution of 99mTc-TMHEA and 99mTc-TMHHA were investigated and compared. The biodistribution studies indicate that the radiotracer 99mTc-TMHEA displays selective tumor uptake, suggesting it is a potential tumor imaging agent.
Keywords: thymidine derivative; 99mTc-labelled; biodistribution; tumor imaging thymidine derivative; 99mTc-labelled; biodistribution; tumor imaging
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Lu, C.; Jiang, Q.; Tan, C.; Tang, J.; Zhang, J. Preparation and Preliminary Biological Evaluation of Novel 99mTc-Labelled Thymidine Analogs as Tumor Imaging Agents. Molecules 2012, 17, 8518-8532.

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