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Molecules 2012, 17(7), 8518-8532; doi:10.3390/molecules17078518

Preparation and Preliminary Biological Evaluation of Novel 99mTc-Labelled Thymidine Analogs as Tumor Imaging Agents

1
Key Laboratory of Nuclear Medicine, Ministry of Health-Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China
2
School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China
*
Author to whom correspondence should be addressed.
Received: 18 May 2012 / Revised: 27 June 2012 / Accepted: 5 July 2012 / Published: 16 July 2012
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Abstract

Two kinds of novel thymidine derivatives, N-thymidine-yl-N′-methyl-N′-{N′′-[2-sulfanyl-(ethylamino)acetyl]-2-aminoethylsulfanyl-1-hexanamide}-ethanediamine (TMHEA) and N-thymidine-yl-N′-methyl-N′-{N′′-[2-sulfanyl-(ethylamino)acetyl]-2-aminoethylsulfanyl-1-hexanamide}-hexanediamine (TMHHA) were prepared and successfully labeled with 99mTc in high labeling yields. The in vitro stability and in vivo biodistribution of 99mTc-TMHEA and 99mTc-TMHHA were investigated and compared. The biodistribution studies indicate that the radiotracer 99mTc-TMHEA displays selective tumor uptake, suggesting it is a potential tumor imaging agent.
Keywords: thymidine derivative; 99mTc-labelled; biodistribution; tumor imaging thymidine derivative; 99mTc-labelled; biodistribution; tumor imaging
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Lu, C.; Jiang, Q.; Tan, C.; Tang, J.; Zhang, J. Preparation and Preliminary Biological Evaluation of Novel 99mTc-Labelled Thymidine Analogs as Tumor Imaging Agents. Molecules 2012, 17, 8518-8532.

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