Molecules 2012, 17(7), 8518-8532; doi:10.3390/molecules17078518
Article

Preparation and Preliminary Biological Evaluation of Novel 99mTc-Labelled Thymidine Analogs as Tumor Imaging Agents

1 Key Laboratory of Nuclear Medicine, Ministry of Health-Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China 2 School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China
* Author to whom correspondence should be addressed.
Received: 18 May 2012; in revised form: 27 June 2012 / Accepted: 5 July 2012 / Published: 16 July 2012
PDF Full-text Download PDF Full-Text [283 KB, uploaded 16 July 2012 11:36 CEST]
Abstract: Two kinds of novel thymidine derivatives, N-thymidine-yl-N′-methyl-N′-{N′′-[2-sulfanyl-(ethylamino)acetyl]-2-aminoethylsulfanyl-1-hexanamide}-ethanediamine (TMHEA) and N-thymidine-yl-N′-methyl-N′-{N′′-[2-sulfanyl-(ethylamino)acetyl]-2-aminoethylsulfanyl-1-hexanamide}-hexanediamine (TMHHA) were prepared and successfully labeled with 99mTc in high labeling yields. The in vitro stability and in vivo biodistribution of 99mTc-TMHEA and 99mTc-TMHHA were investigated and compared. The biodistribution studies indicate that the radiotracer 99mTc-TMHEA displays selective tumor uptake, suggesting it is a potential tumor imaging agent.
Keywords: thymidine derivative; 99mTc-labelled; biodistribution; tumor imaging

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Lu, C.; Jiang, Q.; Tan, C.; Tang, J.; Zhang, J. Preparation and Preliminary Biological Evaluation of Novel 99mTc-Labelled Thymidine Analogs as Tumor Imaging Agents. Molecules 2012, 17, 8518-8532.

AMA Style

Lu C, Jiang Q, Tan C, Tang J, Zhang J. Preparation and Preliminary Biological Evaluation of Novel 99mTc-Labelled Thymidine Analogs as Tumor Imaging Agents. Molecules. 2012; 17(7):8518-8532.

Chicago/Turabian Style

Lu, Chunxiong; Jiang, Quanfu; Tan, Cheng; Tang, Jie; Zhang, Jiankang. 2012. "Preparation and Preliminary Biological Evaluation of Novel 99mTc-Labelled Thymidine Analogs as Tumor Imaging Agents." Molecules 17, no. 7: 8518-8532.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert