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Molecules 2012, 17(7), 8494-8505; doi:10.3390/molecules17078494
Article

Influence of ShuJinHuoXue Tablets on Ischemia Reperfusion Injury of Animals’ Skeletal Muscle

1, 2, 3 and 1,*
1 Hands and Feet Microsurgery, Dalian Municipal Central Hospital, Dalian 116033, China 2 School of Medicine, Dalian University, Dalian 116033, China 3 Orthopedic Department, Changchun University of Traditional Chinese Medicine Affiliated Hospital, Changchun 130021, China
* Author to whom correspondence should be addressed.
Received: 21 May 2012 / Revised: 27 June 2012 / Accepted: 6 July 2012 / Published: 16 July 2012
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Abstract

Ischemia-reperfusion (IR) can lead to serious tissue oxidative injury in animals. ShuJinHuoXue tablet (SJHXT) is a Chinese Traditional Medicine which can relax the muscles and stimulate the blood circulation and has been used as a clinical medicine. In the present study, we investigated the effects of SJHXT pretreatment on oxidative injury using an animal model of acute limb IR. Results showed that SJHXT pre-treatment (200, 300 and 400 mg/kg/day) markedly reduced serum endothelin-1 (ET-1), thromboxane B2 (TXB2) levels and thromboxane B2/6-keto- prostaglandin F1α (TXB2/6-Keto-PGF), wet weight/dried weight (W/D) ratio, myeloperoxidase (MPO), creatine kinase (CK), lactate dehydrogenase (LDH) activities, and increased serum nitric oxide (NO), 6-Keto-PGF levels and NO/ET-1 ratio in the IR+SJHXT groups. In addition, the SJHXT pre-treatment (200, 300 and 400 mg/kg/day) markedly reduced skeletal muscle Ca2+, malondialdehyde (MDA) levels, increased Na+-K+-ATPase, Ca2+-Mg2+-ATPase, superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities. Our results suggest that SJHXT pre-treatment may improve skeletal muscle blood vessel microcirculation, decrease skeletal muscle oxidative injury and enhance antioxidant enzymes activities in IR animals.
Keywords: ShuJinHuoXue tablets; CK; SOD; antioxidant; GSH-Px ShuJinHuoXue tablets; CK; SOD; antioxidant; GSH-Px
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Tong, Z.; Yu, F.; Liu, Z.; Liang, H. Influence of ShuJinHuoXue Tablets on Ischemia Reperfusion Injury of Animals’ Skeletal Muscle. Molecules 2012, 17, 8494-8505.

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