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Molecules 2012, 17(7), 8483-8493; doi:10.3390/molecules17078483

Synthesis, Tautomeric Structure and Antimicrobial Activity of 3-Arylhydrazono-4-phenyl-[1,2,4]-triazepino[2,3-a]quinazoline-2,7(1H)-diones

1
Department of Chemistry, Faculty of Science, University of Cairo, Giza 12311, Egypt
2
Department of Organic Chemistry, National Organization for Drug Control and Research (NODCAR), Giza 12311, Egypt
3
Department of Chemistry, Faculty of Science, Taif University, Taif-888, Saudi Arabia
Present address: Department of Chemistry, Faculty of Science, King Khalid University, P.O. Box 9004, ABHA-61413, Saudi Arabia.
*
Author to whom correspondence should be addressed.
Received: 24 May 2012 / Revised: 25 June 2012 / Accepted: 3 July 2012 / Published: 13 July 2012
(This article belongs to the Section Organic Synthesis)
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Abstract

A simple strategy for the synthesis of the hitherto unreported 3-arylazo-4-phenyl- [1,2,4]triazepino[2,3-a]quinazoline-2,7(1H)-diones is described. Spectral data indicated that the studied compounds exist predominantly in the hydrazone tautomeric form. The antimicrobial activity of the newly synthesized compounds was also evaluated. The results indicated that some of these compounds have moderate activity towards bacteria.
Keywords: azo-hydrazone; tautomerism; [1,2,4]triazepino[2,3-a]quinazolindione; anti-microbial activity azo-hydrazone; tautomerism; [1,2,4]triazepino[2,3-a]quinazolindione; anti-microbial activity
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Farghaly, T.A.R.; Edrees, M.M.; Abdelnabi Mosselhi, M. Synthesis, Tautomeric Structure and Antimicrobial Activity of 3-Arylhydrazono-4-phenyl-[1,2,4]-triazepino[2,3-a]quinazoline-2,7(1H)-diones. Molecules 2012, 17, 8483-8493.

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