Molecules 2012, 17(7), 8483-8493; doi:10.3390/molecules17078483
Article

Synthesis, Tautomeric Structure and Antimicrobial Activity of 3-Arylhydrazono-4-phenyl-[1,2,4]-triazepino[2,3-a]quinazoline-2,7(1H)-diones

Thoraya Abdel Reheem Farghaly 1 email, Mastoura Mohamed Edrees 2,† email and Mosselhi Abdelnabi Mosselhi 1,3,* email
1 Department of Chemistry, Faculty of Science, University of Cairo, Giza 12311, Egypt 2 Department of Organic Chemistry, National Organization for Drug Control and Research (NODCAR), Giza 12311, Egypt 3 Department of Chemistry, Faculty of Science, Taif University, Taif-888, Saudi Arabia † Present address: Department of Chemistry, Faculty of Science, King Khalid University, P.O. Box 9004, ABHA-61413, Saudi Arabia.
* Author to whom correspondence should be addressed.
Received: 24 May 2012; in revised form: 25 June 2012 / Accepted: 3 July 2012 / Published: 13 July 2012
(This article belongs to the Section Organic Synthesis)
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Abstract: A simple strategy for the synthesis of the hitherto unreported 3-arylazo-4-phenyl- [1,2,4]triazepino[2,3-a]quinazoline-2,7(1H)-diones is described. Spectral data indicated that the studied compounds exist predominantly in the hydrazone tautomeric form. The antimicrobial activity of the newly synthesized compounds was also evaluated. The results indicated that some of these compounds have moderate activity towards bacteria.
Keywords: azo-hydrazone; tautomerism; [1,2,4]triazepino[2,3-a]quinazolindione; anti-microbial activity

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MDPI and ACS Style

Farghaly, T.A.R.; Edrees, M.M.; Abdelnabi Mosselhi, M. Synthesis, Tautomeric Structure and Antimicrobial Activity of 3-Arylhydrazono-4-phenyl-[1,2,4]-triazepino[2,3-a]quinazoline-2,7(1H)-diones. Molecules 2012, 17, 8483-8493.

AMA Style

Farghaly TAR, Edrees MM, Abdelnabi Mosselhi M. Synthesis, Tautomeric Structure and Antimicrobial Activity of 3-Arylhydrazono-4-phenyl-[1,2,4]-triazepino[2,3-a]quinazoline-2,7(1H)-diones. Molecules. 2012; 17(7):8483-8493.

Chicago/Turabian Style

Farghaly, Thoraya Abdel Reheem; Edrees, Mastoura Mohamed; Abdelnabi Mosselhi, Mosselhi. 2012. "Synthesis, Tautomeric Structure and Antimicrobial Activity of 3-Arylhydrazono-4-phenyl-[1,2,4]-triazepino[2,3-a]quinazoline-2,7(1H)-diones." Molecules 17, no. 7: 8483-8493.

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