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• Rosselli, S
• Bruno, M
• Raimondo, F
• Spadaro, V
• Varol, M
• Koparal, A
• Maggio, A
• [+] on Google Scholar
• Rosselli, S
• Bruno, M
• Raimondo, F
• Spadaro, V
• Varol, M
• Koparal, A
• Maggio, A
• [+] on PubMed
• Rosselli, S
• Bruno, M
• Raimondo, F
• Spadaro, V
• Varol, M
• Koparal, A
• Maggio, A

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Molecules 2012, 17(7), 8186-8195; doi:10.3390/molecules17078186

Article

Cytotoxic Effect of Eudesmanolides Isolated from Flowers of Tanacetum vulgare ssp. siculum

Sergio Rosselli ^1,* , Maurizio Bruno ¹ , Francesco Maria Raimondo ² , Vivienne Spadaro ² , Mehmet Varol ^1,3 , Ayşe Tansu Koparal ³  and Antonella Maggio ¹

¹ Department of Molecular and Biomolecular Science and Technology (STeMBio), Organic Chemistry Section, Palermo University, Viale delle Scienze, Palermo 90128, Italy ² Department of Environmental Biology and Biodiversity, Palermo University, Via Archirafi 38, Palermo 90123, Italy ³ Department of Biology, Faculty of Science, Anadolu University, Yunusemre Campus, Eskisehir TR 26470, Turkey

* Author to whom correspondence should be addressed.

Received: 24 May 2012; in revised form: 29 June 2012 / Accepted: 2 July 2012 / Published: 9 July 2012

(This article belongs to the Section Natural Products)

Download PDF Full-Text [240 KB, uploaded 9 July 2012 10:00 CEST]

Abstract: A phytochemical analysis of the dichloromethane extract from the flowers of a subspecies of Tanacetum vulgare growing in Sicily was carried out. Five known sesquiterpene lactones with the eudesmane skeleton have been isolated and the cytotoxic activity of these compounds was tested in vitro on A549 (human lung carcinoma epithelial-like) and V79379A (Chinese hamster lung fibroblast-like) cells using the tetrazolium salt reduction (MTT) assay. All of tested compounds induced high time- and concentration-dependent cytotoxic effects.

Keywords: Tanacetum vulgare; sesquiterpenes; eudesmanolides; cytotoxic activity

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