Next Article in Journal
Terpenes as Green Solvents for Extraction of Oil from Microalgae
Previous Article in Journal
Synthesis and Fungicidal Activity of Novel 2,3-Disubstituted-1,3-benzoxazines
Article Menu

Article Versions

Export Article

Open AccessArticle
Molecules 2012, 17(7), 8186-8195; doi:10.3390/molecules17078186

Cytotoxic Effect of Eudesmanolides Isolated from Flowers of Tanacetum vulgare ssp. siculum

Department of Molecular and Biomolecular Science and Technology (STeMBio), Organic Chemistry Section, Palermo University, Viale delle Scienze, Palermo 90128, Italy
Department of Environmental Biology and Biodiversity, Palermo University, Via Archirafi 38, Palermo 90123, Italy
Department of Biology, Faculty of Science, Anadolu University, Yunusemre Campus, Eskisehir TR 26470, Turkey
Author to whom correspondence should be addressed.
Received: 24 May 2012 / Revised: 29 June 2012 / Accepted: 2 July 2012 / Published: 9 July 2012
(This article belongs to the Section Natural Products)
Download PDF [240 KB, uploaded 18 June 2014]


A phytochemical analysis of the dichloromethane extract from the flowers of a subspecies of Tanacetum vulgare growing in Sicily was carried out. Five known sesquiterpene lactones with the eudesmane skeleton have been isolated and the cytotoxic activity of these compounds was tested in vitro on A549 (human lung carcinoma epithelial-like) and V79379A (Chinese hamster lung fibroblast-like) cells using the tetrazolium salt reduction (MTT) assay. All of tested compounds induced high time- and concentration-dependent cytotoxic effects.
Keywords: Tanacetum vulgare; sesquiterpenes; eudesmanolides; cytotoxic activity Tanacetum vulgare; sesquiterpenes; eudesmanolides; cytotoxic activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Rosselli, S.; Bruno, M.; Raimondo, F.M.; Spadaro, V.; Varol, M.; Koparal, A.T.; Maggio, A. Cytotoxic Effect of Eudesmanolides Isolated from Flowers of Tanacetum vulgare ssp. siculum. Molecules 2012, 17, 8186-8195.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top