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Molecules 2012, 17(7), 8186-8195; doi:10.3390/molecules17078186

Cytotoxic Effect of Eudesmanolides Isolated from Flowers of Tanacetum vulgare ssp. siculum

1,* , 1, 2, 2, 1,3, 3 and 1
1 Department of Molecular and Biomolecular Science and Technology (STeMBio), Organic Chemistry Section, Palermo University, Viale delle Scienze, Palermo 90128, Italy 2 Department of Environmental Biology and Biodiversity, Palermo University, Via Archirafi 38, Palermo 90123, Italy 3 Department of Biology, Faculty of Science, Anadolu University, Yunusemre Campus, Eskisehir TR 26470, Turkey
* Author to whom correspondence should be addressed.
Received: 24 May 2012 / Revised: 29 June 2012 / Accepted: 2 July 2012 / Published: 9 July 2012
(This article belongs to the Section Metabolites)
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A phytochemical analysis of the dichloromethane extract from the flowers of a subspecies of Tanacetum vulgare growing in Sicily was carried out. Five known sesquiterpene lactones with the eudesmane skeleton have been isolated and the cytotoxic activity of these compounds was tested in vitro on A549 (human lung carcinoma epithelial-like) and V79379A (Chinese hamster lung fibroblast-like) cells using the tetrazolium salt reduction (MTT) assay. All of tested compounds induced high time- and concentration-dependent cytotoxic effects.
Keywords: Tanacetum vulgare; sesquiterpenes; eudesmanolides; cytotoxic activity Tanacetum vulgare; sesquiterpenes; eudesmanolides; cytotoxic activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Rosselli, S.; Bruno, M.; Raimondo, F.M.; Spadaro, V.; Varol, M.; Koparal, A.T.; Maggio, A. Cytotoxic Effect of Eudesmanolides Isolated from Flowers of Tanacetum vulgare ssp. siculum. Molecules 2012, 17, 8186-8195.

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