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Molecules 2012, 17(7), 8174-8185; doi:10.3390/molecules17078174
Article

Synthesis and Fungicidal Activity of Novel 2,3-Disubstituted-1,3-benzoxazines

1,2,* , 1,2,3
, 1,2
, 1,2
, 1,2
, 1
 and 2,4
Received: 10 June 2012; in revised form: 25 June 2012 / Accepted: 26 June 2012 / Published: 6 July 2012
(This article belongs to the Section Organic Synthesis)
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Abstract: A series of new 2,3-disubstituted-3,4-dihydro-2H-1,3-benzoxazines were prepared in moderate to excellent yields by aza-acetalizations of aromatic aldehydes with 2-(N-substituted aminomethyl)phenols in the presence of TMSCl. Their structures were confirmed by IR, 1H-NMR, 13C-NMR, MS and elemental analysis. The fungicidal activities of the target compounds were preliminarily evaluated, and some compounds exhibited good activity against Rhizoctonia solani.
Keywords: 2,3-disubstituted-1,3-benzoxazine; synthesis; chlorotrimethylsilane; fungicidal activity 2,3-disubstituted-1,3-benzoxazine; synthesis; chlorotrimethylsilane; fungicidal activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Tang, Z.; Zhu, Z.; Xia, Z.; Liu, H.; Chen, J.; Xiao, W.; Ou, X. Synthesis and Fungicidal Activity of Novel 2,3-Disubstituted-1,3-benzoxazines. Molecules 2012, 17, 8174-8185.

AMA Style

Tang Z, Zhu Z, Xia Z, Liu H, Chen J, Xiao W, Ou X. Synthesis and Fungicidal Activity of Novel 2,3-Disubstituted-1,3-benzoxazines. Molecules. 2012; 17(7):8174-8185.

Chicago/Turabian Style

Tang, Zilong; Zhu, Zhonghua; Xia, Zanwen; Liu, Hanwen; Chen, Jinwen; Xiao, Wenjing; Ou, Xiaoming. 2012. "Synthesis and Fungicidal Activity of Novel 2,3-Disubstituted-1,3-benzoxazines." Molecules 17, no. 7: 8174-8185.



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