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Molecules 2012, 17(7), 8159-8173; doi:10.3390/molecules17078159
Article

p-Cymene Protects Mice Against Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting Inflammatory Cell Activation

, , , , , , , *  and *
College of Animal Science and Veterinary Medicine, Jilin University, Changchun 130062, China These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 5 May 2012 / Revised: 3 July 2012 / Accepted: 4 July 2012 / Published: 6 July 2012
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Abstract

The objective of this study was to test the hypothesis that p-cymene can attenuate acute lung injury induced by lipopolysaccharide (LPS) in vivo. In the mouse model of LPS-induced acute lung injury, intraperitoneal preconditioning with p-cymene resulted in a significant reduction of pro-inflammatory cytokines (TNF-α, IL-1β and IL-6), lung water gain, inflammatory cell infiltration, lung tissue myeloperoxidase activity. In addition, p-cymene blocked the phosphorylation of IκBα protein and mitogen-activated protein kinases (MAPK) signaling pathway activation. Histopathologic examination of lung tissue indicated that p-cymene treatment markedly decreased focal thickening, congestion, pulmonary edema, and inflammatory cells infiltration. The results showed that p-cymene had a protective effect on LPS-induced ALI in mice.
Keywords: p-cymene; lipopolysaccharide; acute lung injury p-cymene; lipopolysaccharide; acute lung injury
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Xie, G.; Chen, N.; Soromou, L.W.; Liu, F.; Xiong, Y.; Wu, Q.; Li, H.; Feng, H.; Liu, G. p-Cymene Protects Mice Against Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting Inflammatory Cell Activation. Molecules 2012, 17, 8159-8173.

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