Molecules 2012, 17(7), 7612-7628; doi:10.3390/molecules17077612
Review

Thiadiazines, N,N-Heterocycles of Biological Relevance

Hortensia Rodríguez 1,* email, Margarita Suárez 2 email and Fernando Albericio 1,3,4,* email
1 Institute for Research in Biomedicine, Barcelona Science Park, Baldiri Reixac 10, Barcelona 08028, Spain 2 Laboratory of Organic Synthesis, Department of Organic Chemistry, Faculty of Chemistry, University of Havana, Ciudad Habana 10400, Cuba 3 Department of Organic Chemistry, University of Barcelona, Martí i Franqués 1-11, Barcelona 08028, Spain 4 School of Chemistry, University of KwaZulu-Natal, Durban 4041, South Africa
* Authors to whom correspondence should be addressed.
Received: 7 May 2012; in revised form: 16 June 2012 / Accepted: 19 June 2012 / Published: 25 June 2012
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Abstract: The 3,5-disubstituted tetrahydro-2H-1,3,5-thiadiazine-2-thione scaffold has found many applications in recent years. This review is aimed at highlighting the most important aspects of these compounds: Synthesis, spectroscopic characterization and biological activities. How the chemical nature of N-substituents influences the overall activity and cytotoxicity profile will also be discussed.
Keywords: heterocycles; thiadiazines; synthesis and biological activity

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MDPI and ACS Style

Rodríguez, H.; Suárez, M.; Albericio, F. Thiadiazines, N,N-Heterocycles of Biological Relevance. Molecules 2012, 17, 7612-7628.

AMA Style

Rodríguez H, Suárez M, Albericio F. Thiadiazines, N,N-Heterocycles of Biological Relevance. Molecules. 2012; 17(7):7612-7628.

Chicago/Turabian Style

Rodríguez, Hortensia; Suárez, Margarita; Albericio, Fernando. 2012. "Thiadiazines, N,N-Heterocycles of Biological Relevance." Molecules 17, no. 7: 7612-7628.

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