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Thiadiazines, N,N-Heterocycles of Biological Relevance
Institute for Research in Biomedicine, Barcelona Science Park, Baldiri Reixac 10, Barcelona 08028, Spain
Laboratory of Organic Synthesis, Department of Organic Chemistry, Faculty of Chemistry, University of Havana, Ciudad Habana 10400, Cuba
Department of Organic Chemistry, University of Barcelona, Martí i Franqués 1-11, Barcelona 08028, Spain
School of Chemistry, University of KwaZulu-Natal, Durban 4041, South Africa
* Authors to whom correspondence should be addressed.
Received: 7 May 2012; in revised form: 16 June 2012 / Accepted: 19 June 2012 / Published: 25 June 2012
Abstract: The 3,5-disubstituted tetrahydro-2H-1,3,5-thiadiazine-2-thione scaffold has found many applications in recent years. This review is aimed at highlighting the most important aspects of these compounds: Synthesis, spectroscopic characterization and biological activities. How the chemical nature of N-substituents influences the overall activity and cytotoxicity profile will also be discussed.
Keywords: heterocycles; thiadiazines; synthesis and biological activity
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Rodríguez, H.; Suárez, M.; Albericio, F. Thiadiazines, N,N-Heterocycles of Biological Relevance. Molecules 2012, 17, 7612-7628.
Rodríguez H, Suárez M, Albericio F. Thiadiazines, N,N-Heterocycles of Biological Relevance. Molecules. 2012; 17(7):7612-7628.
Rodríguez, Hortensia; Suárez, Margarita; Albericio, Fernando. 2012. "Thiadiazines, N,N-Heterocycles of Biological Relevance." Molecules 17, no. 7: 7612-7628.