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Terpene Glycosides from the Roots of Sanguisorba officinalis L. and Their Hemostatic Activities
School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China
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Received: 15 May 2012; in revised form: 13 June 2012 / Accepted: 15 June 2012 / Published: 25 June 2012
Abstract: Guided by a hemostasis bioassay, seven terpene glycosides were isolated from the roots of Sanguisorba officinalis L. by silica gel column chromatography and preparative HPLC. On the grounds of chemical and spectroscopic methods, their structures were identified as citronellol-1-O-α-l-arabinofuranosyl-(1→6)-β-d-glucopyranoside (1), geraniol-1-O-α-l-arabinofuranosyl-(1→6)-β-d-glucopyranoside (2), geraniol-1-O-α-l-arabinopyranosyl-(1→6)-β-d-glucopyranoside (3), 3β-[(α-l-arabinopyranosyl)oxy]-19α-hydroxyolean-12-en-28-oic acid 28-β-d-glucopyranoside (4), 3β-[(α-l-arabinopyranosyl)-oxy]-19α-hydroxyurs-12-en-28-oic acid 28-β-d-glucopyranoside (ziyu-glycoside I, 5), 3β,19α-hydroxyolean-12-en-28-oic acid 28-β-d-glucopyranoside (6) and 3β,19α-di-hydroxyurs-12-en-28-oic acid 28-β-d-glucopyranoside (7). Compound 1 is a new mono-terpene glycoside and compounds 2, 3 and 5 were isolated from the Sanguisorba genus for the first time. Compounds 1–7 were assayed for their hemostatic activities with a Goat Anti-Human α2-plasmin inhibitor ELISA kit, and ziyu-glycoside I (5) showed the strongest hemostatic activity among the seven terpene glycosides. This is the first report that ziyu-glycoside Ι has strong hemostatic activity.
Keywords: Sanguisorba officinalis; ziyu-glycoside Ι; citronellol; geraniol; hemostasis
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Sun, W.; Zhang, Z.-L.; Liu, X.; Zhang, S.; He, L.; Wang, Z.; Wang, G.-S. Terpene Glycosides from the Roots of Sanguisorba officinalis L. and Their Hemostatic Activities. Molecules 2012, 17, 7629-7636.
Sun W, Zhang Z-L, Liu X, Zhang S, He L, Wang Z, Wang G-S. Terpene Glycosides from the Roots of Sanguisorba officinalis L. and Their Hemostatic Activities. Molecules. 2012; 17(7):7629-7636.
Sun, Wei; Zhang, Zi-Long; Liu, Xin; Zhang, Shuang; He, Lu; Wang, Zhe; Wang, Guang-Shu. 2012. "Terpene Glycosides from the Roots of Sanguisorba officinalis L. and Their Hemostatic Activities." Molecules 17, no. 7: 7629-7636.