Molecules 2012, 17(6), 7523-7532; doi:10.3390/molecules17067523
Communication

Enantioselective Michael Addition of 3-Aryl-Substituted Oxindoles to Methyl Vinyl Ketone Catalyzed by a Binaphthyl-Modified Bifunctional Organocatalyst

Department of Chemistry, Soonchunhyang University, Asan, Chungnam 336-745, Korea
* Author to whom correspondence should be addressed.
Received: 2 May 2012; in revised form: 6 June 2012 / Accepted: 14 June 2012 / Published: 18 June 2012
(This article belongs to the Special Issue Asymmetric Catalysis)
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Abstract: The enantioselective conjugate addition reaction of 3-aryl-substituted oxindoles with methyl vinyl ketone promoted by binaphthyl-modified bifunctional organocatalysts was investigated. The corresponding Michael adducts, containing a quaternary center at the C3-position of the oxindoles, were generally obtained in high yields with excellent enantioselectivities (up to 91% ee).
Keywords: oxindole; methyl vinyl ketone; conjugate addition; bifunctional organocatalysis; asymmetric catalysis

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MDPI and ACS Style

Lee, H.J.; Woo, S.B.; Kim, D.Y. Enantioselective Michael Addition of 3-Aryl-Substituted Oxindoles to Methyl Vinyl Ketone Catalyzed by a Binaphthyl-Modified Bifunctional Organocatalyst. Molecules 2012, 17, 7523-7532.

AMA Style

Lee HJ, Woo SB, Kim DY. Enantioselective Michael Addition of 3-Aryl-Substituted Oxindoles to Methyl Vinyl Ketone Catalyzed by a Binaphthyl-Modified Bifunctional Organocatalyst. Molecules. 2012; 17(6):7523-7532.

Chicago/Turabian Style

Lee, Hyun Joo; Woo, Saet Byeol; Kim, Dae Young. 2012. "Enantioselective Michael Addition of 3-Aryl-Substituted Oxindoles to Methyl Vinyl Ketone Catalyzed by a Binaphthyl-Modified Bifunctional Organocatalyst." Molecules 17, no. 6: 7523-7532.

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