Molecules 2012, 17(6), 6697-6704; doi:10.3390/molecules17066697
Article

Simple, Rapid and Reliable Preparation of [11C]-(+)-a-DTBZ of High Quality for Routine Applications

Department of Nuclear Medicine, the PLA General Hospital, Beijing 100853, China
* Authors to whom correspondence should be addressed.
Received: 27 April 2012; in revised form: 28 April 2012 / Accepted: 30 April 2012 / Published: 1 June 2012
(This article belongs to the Section Medicinal Chemistry)
PDF Full-text Download PDF Full-Text [180 KB, uploaded 1 June 2012 08:46 CEST]
Abstract: [11C]-(+)-a-DTBZ has been used as a marker of dopaminergic terminal densities in human striatum and expressed in islet beta cells in the pancreas. We aimed to establish a fully automated and simple procedure for the synthesis of [11C]-(+)-a-DTBZ for routine applications. [11C]-(+)-a-DTBZ was synthesized from a 9-hydroxy precursor in acetone and potassium hydroxide with [11C]-methyl triflate and was purified by solid phase extraction using a Vac tC-18 cartridge. Radiochemical yields based on [11C]-methyl triflate (corrected for decay) were 82.3% ± 3.6%, with a specific radioactivity of 60 GBq/mmol. Time elapsed was less than 20 min from end of bombardment to release of the product for quality control.
Keywords: [11C]-(+)-a-DTBZ; VMAT2; position emission tomography; automated synthesis

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Zhang, J.; Zhang, X.; Li, Y.; Tian, J. Simple, Rapid and Reliable Preparation of [11C]-(+)-a-DTBZ of High Quality for Routine Applications. Molecules 2012, 17, 6697-6704.

AMA Style

Zhang J, Zhang X, Li Y, Tian J. Simple, Rapid and Reliable Preparation of [11C]-(+)-a-DTBZ of High Quality for Routine Applications. Molecules. 2012; 17(6):6697-6704.

Chicago/Turabian Style

Zhang, Jinming; Zhang, Xiaojun; Li, Yungang; Tian, Jiahe. 2012. "Simple, Rapid and Reliable Preparation of [11C]-(+)-a-DTBZ of High Quality for Routine Applications." Molecules 17, no. 6: 6697-6704.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert