Molecules 2012, 17(6), 6424-6433; doi:10.3390/molecules17066424
Article

Two New Diterpenoids from the Buds of Wikstroemia chamaedaphne

Jieru Guo 1 , Jinwen Zhang 2 , Penghua Shu 1 , Lingmei Kong 3 , Xincai Hao 1 , Yongbo Xue 1 , Zengwei Luo 1 , Yan Li 3 , Gao Li 1 , Guangmin Yao 1,* email and Yonghui Zhang 1,* email
1 Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China 2 Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China 3 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming 650204, China
* Authors to whom correspondence should be addressed.
Received: 18 April 2012; in revised form: 15 May 2012 / Accepted: 22 May 2012 / Published: 29 May 2012
(This article belongs to the Section Natural Products)
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Abstract: Two new diterpenoids, wikstroelide Q (1) and prostratin Q (5), together with three known diterpenoids, pimelea factors P2 (2), P3 (3), and prostratin (4), and five known lignans, (+)-epipioresinol (6), (+)-isolariciresinol (7), (−)-lariciresinol (8), (+)-epi-sesaminone (9), and prestegane B (10), were isolated from the buds of Wikstroemia chamaedaphne Meissn. Their structures were elucidated by a combination of spectroscopic analyses. Compounds 1–10 were evaluated for their cytotoxicities against HL-60, SMMC-7721, A549, MCF-7, SW480, and BEAS-2B cell lines in vitro.
Keywords: Wikstroemia chamaedaphne; diterpenoids; lignans; cytotoxicity

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Cite This Article

MDPI and ACS Style

Guo, J.; Zhang, J.; Shu, P.; Kong, L.; Hao, X.; Xue, Y.; Luo, Z.; Li, Y.; Li, G.; Yao, G.; Zhang, Y. Two New Diterpenoids from the Buds of Wikstroemia chamaedaphne. Molecules 2012, 17, 6424-6433.

AMA Style

Guo J, Zhang J, Shu P, Kong L, Hao X, Xue Y, Luo Z, Li Y, Li G, Yao G, Zhang Y. Two New Diterpenoids from the Buds of Wikstroemia chamaedaphne. Molecules. 2012; 17(6):6424-6433.

Chicago/Turabian Style

Guo, Jieru; Zhang, Jinwen; Shu, Penghua; Kong, Lingmei; Hao, Xincai; Xue, Yongbo; Luo, Zengwei; Li, Yan; Li, Gao; Yao, Guangmin; Zhang, Yonghui. 2012. "Two New Diterpenoids from the Buds of Wikstroemia chamaedaphne." Molecules 17, no. 6: 6424-6433.

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