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Two New Diterpenoids from the Buds of Wikstroemia chamaedaphne
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming 650204, China
* Authors to whom correspondence should be addressed.
Received: 18 April 2012; in revised form: 15 May 2012 / Accepted: 22 May 2012 / Published: 29 May 2012
Abstract: Two new diterpenoids, wikstroelide Q (1) and prostratin Q (5), together with three known diterpenoids, pimelea factors P2 (2), P3 (3), and prostratin (4), and five known lignans, (+)-epipioresinol (6), (+)-isolariciresinol (7), (−)-lariciresinol (8), (+)-epi-sesaminone (9), and prestegane B (10), were isolated from the buds of Wikstroemia chamaedaphne Meissn. Their structures were elucidated by a combination of spectroscopic analyses. Compounds 1–10 were evaluated for their cytotoxicities against HL-60, SMMC-7721, A549, MCF-7, SW480, and BEAS-2B cell lines in vitro.
Keywords: Wikstroemia chamaedaphne; diterpenoids; lignans; cytotoxicity
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MDPI and ACS Style
Guo, J.; Zhang, J.; Shu, P.; Kong, L.; Hao, X.; Xue, Y.; Luo, Z.; Li, Y.; Li, G.; Yao, G.; Zhang, Y. Two New Diterpenoids from the Buds of Wikstroemia chamaedaphne. Molecules 2012, 17, 6424-6433.
Guo J, Zhang J, Shu P, Kong L, Hao X, Xue Y, Luo Z, Li Y, Li G, Yao G, Zhang Y. Two New Diterpenoids from the Buds of Wikstroemia chamaedaphne. Molecules. 2012; 17(6):6424-6433.
Guo, Jieru; Zhang, Jinwen; Shu, Penghua; Kong, Lingmei; Hao, Xincai; Xue, Yongbo; Luo, Zengwei; Li, Yan; Li, Gao; Yao, Guangmin; Zhang, Yonghui. 2012. "Two New Diterpenoids from the Buds of Wikstroemia chamaedaphne." Molecules 17, no. 6: 6424-6433.