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Molecules 2012, 17(6), 6424-6433; doi:10.3390/molecules17066424
Article

Two New Diterpenoids from the Buds of Wikstroemia chamaedaphne

1, 2, 1, 3, 1, 1, 1, 3, 1, 1,*  and 1,*
1 Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China 2 Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China 3 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming 650204, China
* Authors to whom correspondence should be addressed.
Received: 18 April 2012 / Revised: 15 May 2012 / Accepted: 22 May 2012 / Published: 29 May 2012
(This article belongs to the Section Metabolites)
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Abstract

Two new diterpenoids, wikstroelide Q (1) and prostratin Q (5), together with three known diterpenoids, pimelea factors P2 (2), P3 (3), and prostratin (4), and five known lignans, (+)-epipioresinol (6), (+)-isolariciresinol (7), (−)-lariciresinol (8), (+)-epi-sesaminone (9), and prestegane B (10), were isolated from the buds of Wikstroemia chamaedaphne Meissn. Their structures were elucidated by a combination of spectroscopic analyses. Compounds 110 were evaluated for their cytotoxicities against HL-60, SMMC-7721, A549, MCF-7, SW480, and BEAS-2B cell lines in vitro.
Keywords: Wikstroemia chamaedaphne; diterpenoids; lignans; cytotoxicity Wikstroemia chamaedaphne; diterpenoids; lignans; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Guo, J.; Zhang, J.; Shu, P.; Kong, L.; Hao, X.; Xue, Y.; Luo, Z.; Li, Y.; Li, G.; Yao, G.; Zhang, Y. Two New Diterpenoids from the Buds of Wikstroemia chamaedaphne. Molecules 2012, 17, 6424-6433.

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