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Molecules 2012, 17(6), 6424-6433; doi:10.3390/molecules17066424

Two New Diterpenoids from the Buds of Wikstroemia chamaedaphne

1
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
2
Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
3
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming 650204, China
*
Authors to whom correspondence should be addressed.
Received: 18 April 2012 / Revised: 15 May 2012 / Accepted: 22 May 2012 / Published: 29 May 2012
(This article belongs to the Section Natural Products)
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Abstract

Two new diterpenoids, wikstroelide Q (1) and prostratin Q (5), together with three known diterpenoids, pimelea factors P2 (2), P3 (3), and prostratin (4), and five known lignans, (+)-epipioresinol (6), (+)-isolariciresinol (7), (−)-lariciresinol (8), (+)-epi-sesaminone (9), and prestegane B (10), were isolated from the buds of Wikstroemia chamaedaphne Meissn. Their structures were elucidated by a combination of spectroscopic analyses. Compounds 110 were evaluated for their cytotoxicities against HL-60, SMMC-7721, A549, MCF-7, SW480, and BEAS-2B cell lines in vitro.
Keywords: Wikstroemia chamaedaphne; diterpenoids; lignans; cytotoxicity Wikstroemia chamaedaphne; diterpenoids; lignans; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Guo, J.; Zhang, J.; Shu, P.; Kong, L.; Hao, X.; Xue, Y.; Luo, Z.; Li, Y.; Li, G.; Yao, G.; Zhang, Y. Two New Diterpenoids from the Buds of Wikstroemia chamaedaphne. Molecules 2012, 17, 6424-6433.

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