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Molecules 2012, 17(5), 5952-5971; doi:10.3390/molecules17055952
Article

Antibacterial Evaluation of Some Schiff Bases Derived from 2-Acetylpyridine and Their Metal Complexes

1,* , 1
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1 Chemistry Department, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia 2 Molecular Medicine Department, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia 3 Institute of Biological Science, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
* Author to whom correspondence should be addressed.
Received: 27 March 2012 / Revised: 13 May 2012 / Accepted: 15 May 2012 / Published: 18 May 2012
(This article belongs to the Section Medicinal Chemistry)
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Abstract

A series of Schiff bases derived from 2-acetylpyridne and their metal complexes were characterized by elemental analysis, NMR, FT-IR and UV-Vis spectral studies. The complexes were screened for anti-bacterial activity against Methicillin-resistant Staphylococcus aureus (MRSA), Acinetobacter baumanni (AC), Klebsiella pneumonie (KB) and Pseudomonas aeruginosa (PA) using the disc diffusion and micro broth dilution assays. Based on the overall results, the complexes showed the highest activities against MRSA while a weak antibacterial activity was observed against A. baumanii and P. aeruginosa.
Keywords: Schiff bases; metal complexes; x-ray crystallography; anti-bacteria Schiff bases; metal complexes; x-ray crystallography; anti-bacteria
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Gwaram, N.S.; Ali, H.M.; Khaledi, H.; Abdulla, M.A.; Hadi, A.H.A.; Lin, T.K.; Ching, C.L.; Ooi, C.L. Antibacterial Evaluation of Some Schiff Bases Derived from 2-Acetylpyridine and Their Metal Complexes. Molecules 2012, 17, 5952-5971.

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