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• Gwaram, N
• Ali, H
• Khaledi, H
• Abdulla, M
• Hadi, A
• Lin, T
• Ching, C
• Ooi, C
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• Gwaram, N
• Ali, H
• Khaledi, H
• Abdulla, M
• Hadi, A
• Lin, T
• Ching, C
• Ooi, C
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• Ali, H
• Khaledi, H
• Abdulla, M
• Hadi, A
• Lin, T
• Ching, C
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Molecules 2012, 17(5), 5952-5971; doi:10.3390/molecules17055952

Article

Antibacterial Evaluation of Some Schiff Bases Derived from 2-Acetylpyridine and Their Metal Complexes

Nura Suleiman Gwaram ^1,* , Hapipah Mohd Ali ¹ , Hamid Khaledi ¹ , Mahmood Ameen Abdulla ² , A. Hamid A. Hadi ¹ , Thong Kwai Lin ³ , Chai Lay Ching ³  and Cher Lin Ooi ³

¹ Chemistry Department, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia ² Molecular Medicine Department, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia ³ Institute of Biological Science, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia

* Author to whom correspondence should be addressed.

Received: 27 March 2012; in revised form: 13 May 2012 / Accepted: 15 May 2012 / Published: 18 May 2012

(This article belongs to the Section Medicinal Chemistry)

Download PDF Full-Text [436 KB, uploaded 18 May 2012 10:00 CEST]

Abstract: A series of Schiff bases derived from 2-acetylpyridne and their metal complexes were characterized by elemental analysis, NMR, FT-IR and UV-Vis spectral studies. The complexes were screened for anti-bacterial activity against Methicillin-resistant Staphylococcus aureus (MRSA), Acinetobacter baumanni (AC), Klebsiella pneumonie (KB) and Pseudomonas aeruginosa (PA) using the disc diffusion and micro broth dilution assays. Based on the overall results, the complexes showed the highest activities against MRSA while a weak antibacterial activity was observed against A. baumanii and P. aeruginosa.

Keywords: Schiff bases; metal complexes; x-ray crystallography; anti-bacteria

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