Molecules 2012, 17(5), 5212-5218; doi:10.3390/molecules17055212
Article

Benzyl 2-β-Glucopyranosyloxybenzoate, a New Phenolic Acid Glycoside from Sarcandra glabra

Haifeng Wu 1 email, Xiaoru Hu 1,2 email, Xiaopo Zhang 1 email, Shilin Chen 1 email, Junshan Yang 1 email and Xudong Xu 1,* email
1 Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China 2 National Institutes for Food and Drug Control, Beijing 100050, China
* Author to whom correspondence should be addressed.
Received: 13 April 2012; in revised form: 23 April 2012 / Accepted: 23 April 2012 / Published: 4 May 2012
(This article belongs to the Section Natural Products)
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Abstract: From the whole plant of Sarcandra glabra, a new phenolic acid glycoside, benzyl 2-β-glucopyranosyloxybenzoate (1), together with seven known compounds including eleutheroside B1 (2), 5-O-caffeoylshikimic acid (3), (–)-(7S, 8R)-dihydrodehydro-diconiferyl alcohol (4), (–)-(7S, 8R)-dihydrodehydrodiconiferyl alcohol 9-, 9′- and 4-O-â-D-glucopyranoside (5–7), and (–)-(7S, 8R)-5-methoxydihydrodehydrodiconiferyl alcohol 4-O-β-D-glucopyranoside (8) was isolated. Their structures were elucidated by spectral analysis including 1D-, 2D-NMR and HR-ESI-MS. Compound 2 was found to exhibit potent cytotoxic activity against BGC-823 and A2780 cancer cell lines using MTT method with IC50 value of 2.53 and 1.85 µM, respectively.
Keywords: Sarcandra glabra; chloranthaceae; benzyl 2-β-D-glucopyranosyloxybenzoate; anticancer activity

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Cite This Article

MDPI and ACS Style

Wu, H.; Hu, X.; Zhang, X.; Chen, S.; Yang, J.; Xu, X. Benzyl 2-β-Glucopyranosyloxybenzoate, a New Phenolic Acid Glycoside from Sarcandra glabra. Molecules 2012, 17, 5212-5218.

AMA Style

Wu H, Hu X, Zhang X, Chen S, Yang J, Xu X. Benzyl 2-β-Glucopyranosyloxybenzoate, a New Phenolic Acid Glycoside from Sarcandra glabra. Molecules. 2012; 17(5):5212-5218.

Chicago/Turabian Style

Wu, Haifeng; Hu, Xiaoru; Zhang, Xiaopo; Chen, Shilin; Yang, Junshan; Xu, Xudong. 2012. "Benzyl 2-β-Glucopyranosyloxybenzoate, a New Phenolic Acid Glycoside from Sarcandra glabra." Molecules 17, no. 5: 5212-5218.

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