Abstract: From the whole plant of Sarcandra glabra, a new phenolic acid glycoside, benzyl 2-β-glucopyranosyloxybenzoate (1), together with seven known compounds including eleutheroside B1 (2), 5-O-caffeoylshikimic acid (3), (–)-(7S, 8R)-dihydrodehydro-diconiferyl alcohol (4), (–)-(7S, 8R)-dihydrodehydrodiconiferyl alcohol 9-, 9′- and 4-O-â-D-glucopyranoside (5–7), and (–)-(7S, 8R)-5-methoxydihydrodehydrodiconiferyl alcohol 4-O-β-D-glucopyranoside (8) was isolated. Their structures were elucidated by spectral analysis including 1D-, 2D-NMR and HR-ESI-MS. Compound 2 was found to exhibit potent cytotoxic activity against BGC-823 and A2780 cancer cell lines using MTT method with IC50 value of 2.53 and 1.85 µM, respectively.
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Wu, H.; Hu, X.; Zhang, X.; Chen, S.; Yang, J.; Xu, X. Benzyl 2-β-Glucopyranosyloxybenzoate, a New Phenolic Acid Glycoside from Sarcandra glabra. Molecules 2012, 17, 5212-5218.
Wu H, Hu X, Zhang X, Chen S, Yang J, Xu X. Benzyl 2-β-Glucopyranosyloxybenzoate, a New Phenolic Acid Glycoside from Sarcandra glabra. Molecules. 2012; 17(5):5212-5218.
Wu, Haifeng; Hu, Xiaoru; Zhang, Xiaopo; Chen, Shilin; Yang, Junshan; Xu, Xudong. 2012. "Benzyl 2-β-Glucopyranosyloxybenzoate, a New Phenolic Acid Glycoside from Sarcandra glabra." Molecules 17, no. 5: 5212-5218.