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Molecules 2012, 17(5), 5212-5218; doi:10.3390/molecules17055212
Article

Benzyl 2-β-Glucopyranosyloxybenzoate, a New Phenolic Acid Glycoside from Sarcandra glabra

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Received: 13 April 2012 / Revised: 23 April 2012 / Accepted: 23 April 2012 / Published: 4 May 2012
(This article belongs to the Section Metabolites)
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Abstract

From the whole plant of Sarcandra glabra, a new phenolic acid glycoside, benzyl 2-β-glucopyranosyloxybenzoate (1), together with seven known compounds including eleutheroside B1 (2), 5-O-caffeoylshikimic acid (3), (–)-(7S, 8R)-dihydrodehydro-diconiferyl alcohol (4), (–)-(7S, 8R)-dihydrodehydrodiconiferyl alcohol 9-, 9′- and 4-O-â-D-glucopyranoside (57), and (–)-(7S, 8R)-5-methoxydihydrodehydrodiconiferyl alcohol 4-O-β-D-glucopyranoside (8) was isolated. Their structures were elucidated by spectral analysis including 1D-, 2D-NMR and HR-ESI-MS. Compound 2 was found to exhibit potent cytotoxic activity against BGC-823 and A2780 cancer cell lines using MTT method with IC50 value of 2.53 and 1.85 µM, respectively.
Keywords: Sarcandra glabra; chloranthaceae; benzyl 2-β-D-glucopyranosyloxybenzoate; anticancer activity Sarcandra glabra; chloranthaceae; benzyl 2-β-D-glucopyranosyloxybenzoate; anticancer activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Wu, H.; Hu, X.; Zhang, X.; Chen, S.; Yang, J.; Xu, X. Benzyl 2-β-Glucopyranosyloxybenzoate, a New Phenolic Acid Glycoside from Sarcandra glabra. Molecules 2012, 17, 5212-5218.

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