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Molecules 2012, 17(5), 5219-5224; doi:10.3390/molecules17055219

Phaeophytin Analogues from Ligularia knorringiana

Key Laboratory of Xin Jiang Phytomedicine Resources, School of Pharmacy, Shihezi University, Shihezi 832002, China
Department of Chemistry, Rikkyo University, Nishi-Ikebukuro, Toshima-ku, Tokyo 171-8501, Japan
Author to whom correspondence should be addressed.
Received: 15 March 2012 / Revised: 25 April 2012 / Accepted: 27 April 2012 / Published: 7 May 2012
(This article belongs to the Section Natural Products)
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A new phaeophytin, ligulariaphytin A, together with five known phaeophytins, were isolated from the aerial parts of Ligularia knorringiana. The structure of ligulariaphytin A was elucidated as 131-hydroxy-131,132-peroxyphaeophorbide A ethyl ester (1), and the five known compounds were identified as 132-hydroxyphaeophorbide A ethyl ester (2), 173-ethoxyphaeophorbide A (3), phaeophytin B (4), phaeophytin A (5), and phaeophorbide B ethyl ester (6), respectively, based on spectroscopic analysis and by comparison of their spectral data with those reported previously in the literature. All compounds were evaluated for their in vitro cytotoxic activities against cultured Hela cell, and were found to show only very weak cytotoxicity.
Keywords: Ligularia knorringiana; phaeophytins; ligulariaphytin A Ligularia knorringiana; phaeophytins; ligulariaphytin A

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Li, H.; Li, L.; Zheng, Q.; Kuroda, C.; Wang, Q. Phaeophytin Analogues from Ligularia knorringiana. Molecules 2012, 17, 5219-5224.

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