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Phaeophytin Analogues from Ligularia knorringiana
Key Laboratory of Xin Jiang Phytomedicine Resources, School of Pharmacy, Shihezi University, Shihezi 832002, China
Department of Chemistry, Rikkyo University, Nishi-Ikebukuro, Toshima-ku, Tokyo 171-8501, Japan
* Author to whom correspondence should be addressed.
Received: 15 March 2012; in revised form: 25 April 2012 / Accepted: 27 April 2012 / Published: 7 May 2012
Abstract: A new phaeophytin, ligulariaphytin A, together with five known phaeophytins, were isolated from the aerial parts of Ligularia knorringiana. The structure of ligulariaphytin A was elucidated as 131-hydroxy-131,132-peroxyphaeophorbide A ethyl ester (1), and the five known compounds were identified as 132-hydroxyphaeophorbide A ethyl ester (2), 173-ethoxyphaeophorbide A (3), phaeophytin B (4), phaeophytin A (5), and phaeophorbide B ethyl ester (6), respectively, based on spectroscopic analysis and by comparison of their spectral data with those reported previously in the literature. All compounds were evaluated for their in vitro cytotoxic activities against cultured Hela cell, and were found to show only very weak cytotoxicity.
Keywords: Ligularia knorringiana; phaeophytins; ligulariaphytin A
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MDPI and ACS Style
Li, H.; Li, L.; Zheng, Q.; Kuroda, C.; Wang, Q. Phaeophytin Analogues from Ligularia knorringiana. Molecules 2012, 17, 5219-5224.
Li H, Li L, Zheng Q, Kuroda C, Wang Q. Phaeophytin Analogues from Ligularia knorringiana. Molecules. 2012; 17(5):5219-5224.
Li, Hui; Li, Lina; Zheng, Qiusheng; Kuroda, Chiaki; Wang, Qi. 2012. "Phaeophytin Analogues from Ligularia knorringiana." Molecules 17, no. 5: 5219-5224.