Molecules 2012, 17(5), 5164-5176; doi:10.3390/molecules17055164
Article

Microwave-assisted Solvent-free Synthesis and in Vitro Antibacterial Screening of Quinoxalines and Pyrido[2, 3b]pyrazines

J. Jesús Morales-Castellanos 1 email, Karina Ramírez-Hernández 1 email, Nancy S. Gómez-Flores 1 email, Oscar R. Rodas-Suárez 2 email and Javier Peralta-Cruz 1,* email
1 Department of Organic Chemistry, Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional, Prol. Carpio y Plan de Ayala, México 11340 D. F., Mexico 2 Department of Microbiology, Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional, Prol. Carpio y Plan de Ayala, México 11340 D. F., Mexico
* Author to whom correspondence should be addressed.
Received: 15 March 2012; in revised form: 22 April 2012 / Accepted: 23 April 2012 / Published: 4 May 2012
(This article belongs to the Section Medicinal Chemistry)
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Abstract: We report herein the microwave assisted synthesis, without solvents and catalysts, of 6-substituted quinoxalines and 7-substituted pyrido[2,3b]pyrazines. The compounds were obtained in good yields and short reaction times using the mentioned procedure and two new structures are reported. A complete 1H- and 13C-NMR assignment was performed using 1D and 2D-NMR. Additionally, an in vitro screening was performed on Gram-positive and Gram-negative bacteria using amoxicillin as positive reference. Compounds bearing a pyridyl group tended to have higher antibacterial activity, but the best activity against Bacillus subtilis and Proteus mirabilis was observed with quinoxaline derivatives.
Keywords: 6-substituted quinoxalines; pyrido[2,3b] pyrazines; antimicrobial activity

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MDPI and ACS Style

Morales-Castellanos, J.J.; Ramírez-Hernández, K.; Gómez-Flores, N.S.; Rodas-Suárez, O.R.; Peralta-Cruz, J. Microwave-assisted Solvent-free Synthesis and in Vitro Antibacterial Screening of Quinoxalines and Pyrido[2, 3b]pyrazines. Molecules 2012, 17, 5164-5176.

AMA Style

Morales-Castellanos JJ, Ramírez-Hernández K, Gómez-Flores NS, Rodas-Suárez OR, Peralta-Cruz J. Microwave-assisted Solvent-free Synthesis and in Vitro Antibacterial Screening of Quinoxalines and Pyrido[2, 3b]pyrazines. Molecules. 2012; 17(5):5164-5176.

Chicago/Turabian Style

Morales-Castellanos, J. Jesús; Ramírez-Hernández, Karina; Gómez-Flores, Nancy S.; Rodas-Suárez, Oscar R.; Peralta-Cruz, Javier. 2012. "Microwave-assisted Solvent-free Synthesis and in Vitro Antibacterial Screening of Quinoxalines and Pyrido[2, 3b]pyrazines." Molecules 17, no. 5: 5164-5176.

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