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Molecules 2012, 17(5), 5164-5176; doi:10.3390/molecules17055164

Microwave-assisted Solvent-free Synthesis and in Vitro Antibacterial Screening of Quinoxalines and Pyrido[2, 3b]pyrazines

1
Department of Organic Chemistry, Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional, Prol. Carpio y Plan de Ayala, México 11340 D. F., Mexico
2
Department of Microbiology, Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional, Prol. Carpio y Plan de Ayala, México 11340 D. F., Mexico
*
Author to whom correspondence should be addressed.
Received: 15 March 2012 / Revised: 22 April 2012 / Accepted: 23 April 2012 / Published: 4 May 2012
(This article belongs to the Section Medicinal Chemistry)
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Abstract

We report herein the microwave assisted synthesis, without solvents and catalysts, of 6-substituted quinoxalines and 7-substituted pyrido[2,3b]pyrazines. The compounds were obtained in good yields and short reaction times using the mentioned procedure and two new structures are reported. A complete 1H- and 13C-NMR assignment was performed using 1D and 2D-NMR. Additionally, an in vitro screening was performed on Gram-positive and Gram-negative bacteria using amoxicillin as positive reference. Compounds bearing a pyridyl group tended to have higher antibacterial activity, but the best activity against Bacillus subtilis and Proteus mirabilis was observed with quinoxaline derivatives.
Keywords: 6-substituted quinoxalines; pyrido[2,3b] pyrazines; antimicrobial activity 6-substituted quinoxalines; pyrido[2,3b] pyrazines; antimicrobial activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Morales-Castellanos, J.J.; Ramírez-Hernández, K.; Gómez-Flores, N.S.; Rodas-Suárez, O.R.; Peralta-Cruz, J. Microwave-assisted Solvent-free Synthesis and in Vitro Antibacterial Screening of Quinoxalines and Pyrido[2, 3b]pyrazines. Molecules 2012, 17, 5164-5176.

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