Molecules 2012, 17(5), 5164-5176; doi:10.3390/molecules17055164
Article

Microwave-assisted Solvent-free Synthesis and in Vitro Antibacterial Screening of Quinoxalines and Pyrido[2, 3b]pyrazines

1email, 1email, 1email, 2email and 1,* email
Received: 15 March 2012; in revised form: 22 April 2012 / Accepted: 23 April 2012 / Published: 4 May 2012
(This article belongs to the Section Medicinal Chemistry)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: We report herein the microwave assisted synthesis, without solvents and catalysts, of 6-substituted quinoxalines and 7-substituted pyrido[2,3b]pyrazines. The compounds were obtained in good yields and short reaction times using the mentioned procedure and two new structures are reported. A complete 1H- and 13C-NMR assignment was performed using 1D and 2D-NMR. Additionally, an in vitro screening was performed on Gram-positive and Gram-negative bacteria using amoxicillin as positive reference. Compounds bearing a pyridyl group tended to have higher antibacterial activity, but the best activity against Bacillus subtilis and Proteus mirabilis was observed with quinoxaline derivatives.
Keywords: 6-substituted quinoxalines; pyrido[2,3b] pyrazines; antimicrobial activity
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MDPI and ACS Style

Morales-Castellanos, J.J.; Ramírez-Hernández, K.; Gómez-Flores, N.S.; Rodas-Suárez, O.R.; Peralta-Cruz, J. Microwave-assisted Solvent-free Synthesis and in Vitro Antibacterial Screening of Quinoxalines and Pyrido[2, 3b]pyrazines. Molecules 2012, 17, 5164-5176.

AMA Style

Morales-Castellanos JJ, Ramírez-Hernández K, Gómez-Flores NS, Rodas-Suárez OR, Peralta-Cruz J. Microwave-assisted Solvent-free Synthesis and in Vitro Antibacterial Screening of Quinoxalines and Pyrido[2, 3b]pyrazines. Molecules. 2012; 17(5):5164-5176.

Chicago/Turabian Style

Morales-Castellanos, J. Jesús; Ramírez-Hernández, Karina; Gómez-Flores, Nancy S.; Rodas-Suárez, Oscar R.; Peralta-Cruz, Javier. 2012. "Microwave-assisted Solvent-free Synthesis and in Vitro Antibacterial Screening of Quinoxalines and Pyrido[2, 3b]pyrazines." Molecules 17, no. 5: 5164-5176.

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