Next Article in Journal
Synthesis of Electronically Modified Ru-Based Neutral 16 VE Allenylidene Olefin Metathesis Precatalysts
Previous Article in Journal
A Facile One-Pot Process for the Formation of Hindered Tertiary Amines
Molecules 2012, 17(5), 5164-5176; doi:10.3390/molecules17055164
Article

Microwave-assisted Solvent-free Synthesis and in Vitro Antibacterial Screening of Quinoxalines and Pyrido[2, 3b]pyrazines

1
,
1
,
1
,
2
 and
1,*
1 Department of Organic Chemistry, Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional, Prol. Carpio y Plan de Ayala, México 11340 D. F., Mexico 2 Department of Microbiology, Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional, Prol. Carpio y Plan de Ayala, México 11340 D. F., Mexico
* Author to whom correspondence should be addressed.
Received: 15 March 2012 / Revised: 22 April 2012 / Accepted: 23 April 2012 / Published: 4 May 2012
(This article belongs to the Section Medicinal Chemistry)
Download PDF [241 KB, uploaded 18 June 2014]

Abstract

We report herein the microwave assisted synthesis, without solvents and catalysts, of 6-substituted quinoxalines and 7-substituted pyrido[2,3b]pyrazines. The compounds were obtained in good yields and short reaction times using the mentioned procedure and two new structures are reported. A complete 1H- and 13C-NMR assignment was performed using 1D and 2D-NMR. Additionally, an in vitro screening was performed on Gram-positive and Gram-negative bacteria using amoxicillin as positive reference. Compounds bearing a pyridyl group tended to have higher antibacterial activity, but the best activity against Bacillus subtilis and Proteus mirabilis was observed with quinoxaline derivatives.
Keywords: 6-substituted quinoxalines; pyrido[2,3b] pyrazines; antimicrobial activity 6-substituted quinoxalines; pyrido[2,3b] pyrazines; antimicrobial activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
SciFeed

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
RIS
MDPI and ACS Style

Morales-Castellanos, J.J.; Ramírez-Hernández, K.; Gómez-Flores, N.S.; Rodas-Suárez, O.R.; Peralta-Cruz, J. Microwave-assisted Solvent-free Synthesis and in Vitro Antibacterial Screening of Quinoxalines and Pyrido[2, 3b]pyrazines. Molecules 2012, 17, 5164-5176.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert