Molecules 2012, 17(5), 5151-5163; doi:10.3390/molecules17055151
Communication

A Facile One-Pot Process for the Formation of Hindered Tertiary Amines

Zhouyu Wang 1,* email, Dong Pei 2 , Yu Zhang 2 , Chao Wang 2  and Jian Sun 2,* email
1 Department of Pharmaceutics Engineering, Xihua University, Chengdu 610039, China 2 Natural Products Research Center, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China
* Authors to whom correspondence should be addressed.
Received: 4 April 2012; in revised form: 25 April 2012 / Accepted: 25 April 2012 / Published: 3 May 2012
(This article belongs to the Section Organic Synthesis)
PDF Full-text Download PDF Full-Text [232 KB, uploaded 3 May 2012 11:44 CEST]
Abstract: A simple and convenient method was developed for the preparation of hindered tertiary amines via direct reductive amination of ketones with secondary aryl amines, using trichlorosilane as reducing agent and tetramethylethylenediamine (TMEDA) as organic Lewis base activator. A broad range of ketones were reacted with N-methylaniline to afford the corresponding tertiary amine products in high yield. An open transition model was proposed for the reductive step.
Keywords: reductive amination; tertiary amine; Lewis base; trichlorosilane; ketone

Supplementary Files

Article Statistics

Click here to load and display the download statistics.

Cite This Article

MDPI and ACS Style

Wang, Z.; Pei, D.; Zhang, Y.; Wang, C.; Sun, J. A Facile One-Pot Process for the Formation of Hindered Tertiary Amines. Molecules 2012, 17, 5151-5163.

AMA Style

Wang Z, Pei D, Zhang Y, Wang C, Sun J. A Facile One-Pot Process for the Formation of Hindered Tertiary Amines. Molecules. 2012; 17(5):5151-5163.

Chicago/Turabian Style

Wang, Zhouyu; Pei, Dong; Zhang, Yu; Wang, Chao; Sun, Jian. 2012. "A Facile One-Pot Process for the Formation of Hindered Tertiary Amines." Molecules 17, no. 5: 5151-5163.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert