Abstract: Sixteen novel pyrazole acyl thiourea derivatives 6 were synthesized from monomethylhydrazine (phenylhydrazine) and ethyl acetoacetate. The key 5-chloro-3-methyl-1-substituted-1H-pyrazole-4-carbonyl chloride intermediates 4 were first generated in four steps through cyclization, formylation, oxidation and acylation. Thess were then reacted with ammonium thiocyanate in the presence of PEG-400 to afford 5-chloro-3-methyl-1-substituted-1H-pyrazole-4-carbonyl isothiocyanates 5. Subsequent reaction with fluorinated aromatic amines resulted in the formation of the title compounds. The synthesized compound were unequivocally characterized by IR, 1H-NMR, 13C-NMR and elemental analysis and some of the synthesized compounds displayed good antifungal activities against Gibberella zeae, Fusarium oxysporum, Cytospora mandshurica and anti-TMV activity in preliminary antifungal activity tests.
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Wu, J.; Shi, Q.; Chen, Z.; He, M.; Jin, L.; Hu, D. Synthesis and Bioactivity of Pyrazole Acyl Thiourea Derivatives. Molecules 2012, 17, 5139-5150.
Wu J, Shi Q, Chen Z, He M, Jin L, Hu D. Synthesis and Bioactivity of Pyrazole Acyl Thiourea Derivatives. Molecules. 2012; 17(5):5139-5150.
Wu, Jian; Shi, Qing; Chen, Zhuo; He, Ming; Jin, Linhong; Hu, Deyu. 2012. "Synthesis and Bioactivity of Pyrazole Acyl Thiourea Derivatives." Molecules 17, no. 5: 5139-5150.