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Evaluation of Antioxidant and Immunity Activities of Quercetin in Isoproterenol-Treated Rats
Department of Cardiology, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, Shaanxi, China
Department of Internal Medicine, The People’s Hospital of Long Xian, Long Xian 721200, Shaanxi, China
* Author to whom correspondence should be addressed.
Received: 21 March 2012; in revised form: 21 March 2012 / Accepted: 22 March 2012 / Published: 10 April 2012
Abstract: The present study was designed to evaluate the effect of quercetin on myocardial oxidative stress and immunity function impairment induced by isoproterenol in rats. To induce myocardial ischemia, Wistar rats were subcutaneously injected with isoproterenol (70 mg/kg). Blood immunity index, cardiac marker enzymes and antioxidative parameters in hearts were measured. It was found that the levels of blood AST, creatine kinase, NO, NOS, IL-10, IL-1, IL-8 and lactate dehydrogenase in isoproterenol-treated rats were significantly increased. The rats administrated with isoproterenol showed the declines in myocardial antioxidant enzymes activities. Administration of quercetin significantly ameliorated myocardial oxidative injury and immunity function impairment induced by isoproterenol. The results indicated that quercetin possesses activity against isoproterenol-induced myocardial oxidative injury and immunity function impairment, and that the mechanism of pharmacological action was related at least in part to the antioxidant activity of quercetin.
Keywords: isoproterenol; quercetin; ischemia; myocardial; antioxidant; immunity
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Cite This Article
MDPI and ACS Style
Liu, H.; Zhang, L.; Lu, S. Evaluation of Antioxidant and Immunity Activities of Quercetin in Isoproterenol-Treated Rats. Molecules 2012, 17, 4281-4291.
Liu H, Zhang L, Lu S. Evaluation of Antioxidant and Immunity Activities of Quercetin in Isoproterenol-Treated Rats. Molecules. 2012; 17(4):4281-4291.
Liu, Hui; Zhang, Lei; Lu, Shaoping. 2012. "Evaluation of Antioxidant and Immunity Activities of Quercetin in Isoproterenol-Treated Rats." Molecules 17, no. 4: 4281-4291.