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Anti-inflammatory Activity of Hautriwaic Acid Isolated from Dodonaea viscosa Leaves
Biodiversity and Conservation Research Center. (UAEM), Av. Universidad 1001, Col. Chamilpa, Cuernavaca 62209, Morelos, Mexico
Biomedical Research Center of the South (IMSS), Argentina 1, Col. Centro, Xochitepec 62790, Morelos, Mexico
Department of Biological Systems, (UAM-Xochimilco), Calzada del Hueso 1100, Col. Villa Quietud, México D.F. 04960, Mexico
* Author to whom correspondence should be addressed.
Received: 10 February 2012; in revised form: 10 March 2012 / Accepted: 15 March 2012 / Published: 10 April 2012
Abstract: The aim of this study was to identify an anti-inflammatory compound from D. viscosa leaves. The structure of this bioactive substance was elucidated by IR and NMR studies, which indicated that this natural product corresponds to hautriwaic acid (HA). This diterpene exhibited good anti-inflammatory activity in 12-O-tetradecanoylphorbol 13-acetate (TPA) mice ear edema models by applications at doses of 0.25, 0.5 and 1.0 mg/ear (60.2, 70.2 and 87.1% inhibition, respectively); additionally Dodonaea viscosa dichloro-methane extract (DvDE) displays a 97.8% anti-inflammatory effect at 3 mg/kg. Multiple applications of DvDE at doses of 100 mg/kg on TPA mice ear edema inhibited the edema-associated inflammation by 71.8%, while HA at doses of 15 mg/kg, reduced edema to 64% and indomethacin 40%.
Keywords: anti-inflammatory activity; Dodonaea viscosa; hautriwaic acid; TPA
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Salinas-Sánchez, D.O.; Herrera-Ruiz, M.; Pérez, S.; Jiménez-Ferrer, E.; Zamilpa, A. Anti-inflammatory Activity of Hautriwaic Acid Isolated from Dodonaea viscosa Leaves. Molecules 2012, 17, 4292-4299.
Salinas-Sánchez DO, Herrera-Ruiz M, Pérez S, Jiménez-Ferrer E, Zamilpa A. Anti-inflammatory Activity of Hautriwaic Acid Isolated from Dodonaea viscosa Leaves. Molecules. 2012; 17(4):4292-4299.
Salinas-Sánchez, David Osvaldo; Herrera-Ruiz, Maribel; Pérez, Salud; Jiménez-Ferrer, Enrique; Zamilpa, Alejandro. 2012. "Anti-inflammatory Activity of Hautriwaic Acid Isolated from Dodonaea viscosa Leaves." Molecules 17, no. 4: 4292-4299.